Author name: Kristen Hartman

The role of orexin in sexual behavior and sexual reward of the male rat

Di Sebastiano AR, Yong-yow S, Coolen LM (2008) The role of orexin in sexual behavior and sexual reward of the male rat. Neuroscience 2008 Abstracts 97.4/UU18. Society for Neuroscience, Washington, DC. Summary: The hypothalamic neuropeptide orexin has been demonstrated to play a role in reward related to drugs of abuse and is potentially involved in […]

The role of orexin in sexual behavior and sexual reward of the male rat Read More »

The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions.

Kalinchuk AV, McCarley RW, Stenberg D, Porkka-Heiskanen T, Basheer R (2008) The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience 157:238-253. doi: 10.1016/j.neuroscience.2008.08.040 Summary: The level of adenosine in the basal forebrain increases during sleep deprivation (SD). The cholinergic system of the basal forebrain is

The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Read More »

Renal sympathoinhibition induced by hypernatremia: Involvement of A1 noradrenergic neurons.

Pedrino GR, Rosa DA, Korim WS, Cravo SL (2008) Renal sympathoinhibition induced by hypernatremia: Involvement of A1 noradrenergic neurons. Auton Neurosci 142(1-2):55-63. doi: 10.1016/j.autneu.2008.06.006 Summary: A1 noradrenergic neurons in the caudal ventrolateral medulla (CVLM) are thought to contribute to body fluid homeostasis and cardiovascular regulation. In order to examine the role these neurons play on

Renal sympathoinhibition induced by hypernatremia: Involvement of A1 noradrenergic neurons. Read More »

Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure.

Bienkowski MS, Rinaman L (2008) Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Neuroscience 156(4):1093-1102. doi: 10.1016/j.neuroscience.2008.08.011 Summary: Noradrenergic (NA) neurons in the central nervous system are activated during the immune response to systemic lipopolysaccharide (LPS). The authors tested whether these neurons

Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Read More »

Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats.

Craig LA, Hong NS, Kopp J, McDonald RJ (2009) Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats. Exp Brain Res 193(1):29-42. doi: 10.1007/s00221-008-1592-5 Summary: Recent work has suggested that reduced levels of acetylcholine, seen in Alzheimer’s disease patients, increases the susceptibility of hippocampal neurons to future challenges.

Selective lesion of medial septal cholinergic neurons followed by a mini-stroke impairs spatial learning in rats. Read More »

Targeting Tools: Anti-Saporin

News Tools /

Saporin is a plant enzyme with N-glycosidase activity that depurinates a specific nucleotide in the ribosomal RNA 28S, thus irreversibly blocking protein synthesis. Affinity-purified Anti-Saporin rabbit polyclonal (Cat. #AB-41AP) is the most recent addition to our line of Saporin antibodies. These antibodies can be used as controls with our Saporin-conjugate immunotoxins, for immunoblotting, and in

Targeting Tools: Anti-Saporin Read More »

Saporin Clearance

Q: I am planning an experiment to investigate the effects of ablation of spinal NK-1r-expressing cells (using intrathecal injection of SSP-SAP, Cat. #IT-11). In the first part of the experiment I want to destroy the NK-1r-expressing cells before surgical modification. I am unsure how long after injection of SSP-SAP I should carry out the surgery.

Saporin Clearance Read More »

Featured Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in conditioned fear

Likhtik E (2008) Featured Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in conditioned fear. Targeting Trends 9(4) Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: Likhtik E et al. Amygdala intercalated neurons are required for expression of

Featured Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in conditioned fear Read More »

Targeting Article: Control Circadian Rhythm?

News Article /

Advanced Targeting Systems announces the release of Melanopsin-SAP (Cat. #IT-44), a reagent that specifically eliminates intrinsically photosensitive retinal ganglion cells (ipRGCs) that contain melanopsin. This material is described in Göz et al.[1] and consists of an antibody to an extracellular domain conjugated to saporin. The ipRGCs, with their amazing long processes, have become major players

Targeting Article: Control Circadian Rhythm? Read More »

Search
Shopping Cart
Scroll to Top