Author name: Kristen Hartman

Cover Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in extinction of conditioned fear.

News Article /

Contributed by Ekaterina Likhtik Columbia University,New York Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032 Introduction by Douglas Lappi, Ph.D., President/CSO: This quarter’s Cover Article is from Ekaterina Likhtik who reprises her recently published work in Nature 454:642-645. In the News and Views, Sah and Westbrook comment that “Neuronal receptors in these circuits—such as […]

Cover Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in extinction of conditioned fear. Read More »

Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain.

Murillo-Rodriguez E, Liu M, Blanco-Centurion C, Shiromani PJ (2008) Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain. Eur J Neurosci 28(6):1191-1198. doi: 10.1111/j.1460-9568.2008.06424.x Summary: Adenosine levels in the basal forebrain are thought to regulate the waxing and waning of sleep drive. Rats received bilateral 100-ng injections

Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain. Read More »

Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms.

Göz D, Studholme K, Lappi DA, Rollag MD, Provencio I, Morin LP (2008) Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms. PLoS ONE 3(9):e3153. doi: 10.1371/journal.pone.0003153 PMID: 18773079 Summary: Retinal ganglion cells expressing melanopsin photopigment are thought to be involved in non-image forming

Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms. Read More »

Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats

Iwatsuki K, Yoshimine T, Kishima H, Aoki M, Yoshimura K, Ishihara M, Ohnishi Y, Lima C (2008) Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats. Neuroreport 19(13):1249-1252. doi: 10.1097/WNR.0b013e328305b70b PMID: 18695502 Related Products: NGFr (192-IgG, p75) Mouse Monoclonal (Cat. #AB-N43)

Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats Read More »

Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion.

Mandolesi L, De Bartolo P, Foti F, Gelfo F, Federico F, Leggio MG, Petrosini L (2008) Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion. J Alzheimers Dis 15:11-28. doi: 10.3233/jad-2008-15102 PMID: 18780964 Summary: The cognitive reserve model suggests individuals can develop resources that reduce the risk of later

Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion. Read More »

The p75 receptor is associated with inflammatory thermal hypersensitivity.

Watanabe T, Ito T, Inoue G, Ohtori S, Kitajo K, Doya H, Takahashi K, Yamashita T (2008) The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res 86:3566-3574. doi: 10.1002/jnr.21808 PMID: 18709654 Summary: Inflammation, which can lead to pain hypersensitivity, not only elevates NGF levels, but also can increase the sensitivity of high-threshold

The p75 receptor is associated with inflammatory thermal hypersensitivity. Read More »

Lesions of medullary catecholaminergic neurons increase salt intake in rats.

Colombari DS, Pedrino GR, Freiria-Oliveira AH, Korim WS, Maurino IC, Cravo SL (2008) Lesions of medullary catecholaminergic neurons increase salt intake in rats. Brain Res Bull 76:572-578. doi: 10.1016/j.brainresbull.2008.04.001 Summary: Catecholaminergic neurons in the caudal ventrolateral medulla (CVLM) are thought to contribute to cardiovascular regulation and body fluid homeostasis. Bilateral 6.3-ng injections of anti-DBH-SAP (Cat.

Lesions of medullary catecholaminergic neurons increase salt intake in rats. Read More »

Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries.

Liao D, Lin PH, Yao Q, Chen C (2008) Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Biochem Biophys Res Commun 372(4):668-673. doi: 10.1016/j.bbrc.2008.05.117 Summary: Basic fibroblast growth factor is highly effective in stimulating smooth muscle cell (SMC) proliferation. The authors used FGF-SAP (Cat. #IT-38) to help characterize a model of vascular

Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Read More »

An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells.

Harle P, Pongratz G, Albrecht J, Tarner IH, Straub RH (2008) An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum 58:2347-2355. doi: 10.1002/art.23628 Summary: The sympathetic nervous system can play conflicting roles in collagen-induced arthritis (CIA). CD4+CD25+ T cells can play an immunoregulatory effect in this system depending on the

An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Read More »

Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory.

Wisman L, Sahin G, Maingay M, Leanza G, Kirik D (2008) Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory. J Neurosci 28:7797-7807. doi: 10.1523/JNEUROSCI.1885-08.2008 Summary: Analysis of cholinergic alterations in PD patients may help to understand and treat the nonmotor symptoms of the disease. Usage: Cholinergic neurons in theNBMand the

Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory. Read More »

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