Author name: Kristen Hartman

Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures.

Craig LA, Hong NS, Kopp J, McDonald RJ (2008) Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures. Hippocampus 18(11):1112-1121. doi: 10.1002/hipo.20471 Summary: The loss of cholinergic neurons in the medial septum and seizures are both associated with Alzheimer’s disease. The authors investigated links between these factors using […]

Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures. Read More »

Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates.

Dotigny F, Ben Amor AY, Burke M, Vaucher E (2008) Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates. Neuroscience 154(4):1607-1618. doi: 10.1016/j.neuroscience.2008.04.030 Summary: Acetylcholine is thought to have a neuromodulatory role in visual processing. After rats were treated with 192-IgG-SAP (Cat. #IT-01, 2 µl of 2.4 µg/µl into the lateral ventricle)

Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates. Read More »

Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress.

Radley JJ, Williams B, Sawchenko PE (2008) Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. J Neurosci 28:5806-5816. doi: 10.1523/JNEUROSCI.0552-08.2008 Summary: Hypothalamo-pituitary-adrenal (HPA) responses to emotional stress are in part controlled by the medial prefrontal cortex (mPFC). The locus ceruleus (LC) is also thought to be involved in

Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. Read More »

Amygdala intercalated neurons are required for expression of fear extinction.

Likhtik E, Popa D, Apergis-Schoute J, Fidacaro GA, Pare D (2008) Amygdala intercalated neurons are required for expression of fear extinction. Nature 454(7204):642-645. doi: 10.1038/nature07167 Summary: Scientists have been using fear learning in animals to study human anxiety disorders. In order to investigate the contribution of amygdala plasticity to fear learning, rats received 0.25-µl bilateral

Amygdala intercalated neurons are required for expression of fear extinction. Read More »

Apoptosis or Necrosis?

Q: Do targeted toxin-treated cells die by apoptosis? A: There are, allegedly, two ways for cells to die: by apoptosis or necrosis. According to Fiorenzo Stirpe (the discoverer of saporin), saporin-intoxicated cells die both ways, some by one, others by the other. There is good literature that states that cells die by apoptosis. Saporin and

Apoptosis or Necrosis? Read More »

Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells.

Zhao XY, Liu HL, Liu B, Willuda J, Siemeister G, Mahmoudi M, Dinter H (2008) Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells. Transl Oncol 1:102-109. doi: 10.1593/tlo.08124 Summary: Tomoregulin is a type 1 transmembrane protein with a short cytoplasmic tail, and is found in the brain and prostate. After confirming cell

Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells. Read More »

Featured Article: Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress

Radley JJ (2008) Featured Article: Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. Targeting Trends 9(3) Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) Read the featured article in Targeting Trends. See Also: Radley JJ et al. Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal

Featured Article: Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress Read More »

Cover Article: Noradrenergic Innervation of the Dorsal Medial Prefrontal Cortex Modulates Hypothalamo-Pituitary-Adrenal Responses to Acute Emotional Stress

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Contributed by Jason J. Radley, Ph.D., Laboratory of Neuronal Structure and FunctionThe Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, CA 92037, USA The medial prefrontal cortex (mPFC) has been proposed to play a role in the inhibition of hypothalamo-pituitary-adrenal (HPA) responses to emotional stress via influences on neuroendocrine effector mechanisms

Cover Article: Noradrenergic Innervation of the Dorsal Medial Prefrontal Cortex Modulates Hypothalamo-Pituitary-Adrenal Responses to Acute Emotional Stress Read More »

Unilateral ablation of preBotzinger Complex disrupts breathing during sleep but not wakefulness.

McKay LC, Feldman JL (2008) Unilateral ablation of preBotzinger Complex disrupts breathing during sleep but not wakefulness. Am J Respir Crit Care Med 178(1):89-95. doi: 10.1164/rccm.200712-1901OC Summary: Previous data has shown that ablation of preBötzinger complex (preBötC) neurokinin 1 expressing (NK1R) neurons disrupts breathing patterns in both sleep and wakefulness. The initial disruption is during

Unilateral ablation of preBotzinger Complex disrupts breathing during sleep but not wakefulness. Read More »

GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.

Bogen O, Joseph EK, Chen X, Levine JD (2008) GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci 28:12-19. doi: 10.1111/j.1460-9568.2008.06308.x Summary: C-fiber nociceptors have been divided into NGF and GDNF classes. Here the authors examined the function of an

GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Read More »

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