Targeting Article: Control Circadian Rhythm?

Advanced Targeting Systems announces the release of Melanopsin-SAP (Cat. #IT-44), a reagent that specifically eliminates intrinsically photosensitive retinal ganglion cells (ipRGCs) that contain melanopsin. This material is described in Göz et al.[1] and consists of an antibody to an extracellular domain conjugated to saporin. The ipRGCs, with their amazing long processes, have become major players in the perception of light and dark, and their role as circadian rhythm determinants is a hot topic. Use this new tool to determine who’s right!

1. Göz D, Studholme K, Lappi DA, Rollag MD, Provencio I, Morin LP Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms. PLoS One 3(9), e3153, 2008


Intrinsically photosensitive retinal ganglion cells – ipRGCs – were discovered in 2002.[2]
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