Zhao XY, Liu HL, Liu B, Willuda J, Siemeister G, Mahmoudi M, Dinter H (2008) Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells. Transl Oncol 1:102-109. doi: 10.1593/tlo.08124 Summary: Tomoregulin is a type 1 transmembrane protein with a short cytoplasmic tail, and is found in the brain and prostate. After confirming cell […]
Radley JJ (2008) Featured Article: Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. Targeting Trends 9(3) Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) Read the featured article in Targeting Trends. See Also: Radley JJ et al. Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal
Contributed by Jason J. Radley, Ph.D., Laboratory of Neuronal Structure and FunctionThe Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, CA 92037, USA The medial prefrontal cortex (mPFC) has been proposed to play a role in the inhibition of hypothalamo-pituitary-adrenal (HPA) responses to emotional stress via influences on neuroendocrine effector mechanisms
McKay LC, Feldman JL (2008) Unilateral ablation of preBotzinger Complex disrupts breathing during sleep but not wakefulness. Am J Respir Crit Care Med 178(1):89-95. doi: 10.1164/rccm.200712-1901OC Summary: Previous data has shown that ablation of preBötzinger complex (preBötC) neurokinin 1 expressing (NK1R) neurons disrupts breathing patterns in both sleep and wakefulness. The initial disruption is during
Bogen O, Joseph EK, Chen X, Levine JD (2008) GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci 28:12-19. doi: 10.1111/j.1460-9568.2008.06308.x Summary: C-fiber nociceptors have been divided into NGF and GDNF classes. Here the authors examined the function of an
Belton RJ Jr (2008) Basigin-2 is a cell surface receptor for soluble basigin ligand. J Biol Chem 283(26):17805-17814. doi: 10.1074/jbc.M801876200 PMID: 18434307 Related Products: Antibody to Basigin (Cat. #AB-42)
Basigin-2 is a cell surface receptor for soluble basigin ligand. Read More »
De Bartolo P, Leggio MG, Mandolesi L, Foti F, Gelfo F, Ferlazzo F, Petrosini L (2008) Environmental enrichment mitigates the effects of basal forebrain lesions on cognitive flexibility. Neuroscience 154(2):444-453. doi: 10.1016/j.neuroscience.2008.03.069 Summary: The basal forebrain cholinergic system is a crucial participant in various facets of learning and memory. This work examines whether environmental enrichment
Zinck ND, Downie JW (2008) IB4 afferent sprouting contributes to bladder dysfunction in spinal rats. Exp Neurol 213:293-302. doi: 10.1016/j.expneurol.2008.06.006 Summary: Spinal cord injury can cause inefficient bladder function, but the direct cause is not well understood. Most work has focused on afferent neurons that contain CGRP and respond to NGF. Here the authors investigate
IB4 afferent sprouting contributes to bladder dysfunction in spinal rats. Read More »
Yu S, Xie H, Datta A, Naidu N, Gu XX (2008) Galactose residues on the lipooligosaccharide (LOS) of moraxella catarrhalis 26404 (serotype c) form the epitope recognized by the bactericidal antiserum from conjugate vaccination. Infect Immun 76(9):4251-4258. doi: 10.1128/IAI.01570-07 Related Products: Goat Anti-Rabbit IgG, FITC-labeled (Cat. #FL-04)
Takakura AC, Moreira TS, Stornetta RL, West GH, Gwilt JM, Guyenet PG (2008) Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apneic threshold in rats. J Physiol 586:2975-2991. doi: 10.1113/jphysiol.2008.153163 Summary: It is thought that transcription factor Phox2b-expressing glutamatergic interneurons are involved in the activation of breathing by elevated CO2 in the central nervous system.