Author name: Kristen Hartman

The p75 receptor is associated with inflammatory thermal hypersensitivity.

Watanabe T, Ito T, Inoue G, Ohtori S, Kitajo K, Doya H, Takahashi K, Yamashita T (2008) The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res 86:3566-3574. doi: 10.1002/jnr.21808 PMID: 18709654 Summary: Inflammation, which can lead to pain hypersensitivity, not only elevates NGF levels, but also can increase the sensitivity of high-threshold […]

The p75 receptor is associated with inflammatory thermal hypersensitivity. Read More »

Lesions of medullary catecholaminergic neurons increase salt intake in rats.

Colombari DS, Pedrino GR, Freiria-Oliveira AH, Korim WS, Maurino IC, Cravo SL (2008) Lesions of medullary catecholaminergic neurons increase salt intake in rats. Brain Res Bull 76:572-578. doi: 10.1016/j.brainresbull.2008.04.001 Summary: Catecholaminergic neurons in the caudal ventrolateral medulla (CVLM) are thought to contribute to cardiovascular regulation and body fluid homeostasis. Bilateral 6.3-ng injections of anti-DBH-SAP (Cat.

Lesions of medullary catecholaminergic neurons increase salt intake in rats. Read More »

Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries.

Liao D, Lin PH, Yao Q, Chen C (2008) Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Biochem Biophys Res Commun 372(4):668-673. doi: 10.1016/j.bbrc.2008.05.117 Summary: Basic fibroblast growth factor is highly effective in stimulating smooth muscle cell (SMC) proliferation. The authors used FGF-SAP (Cat. #IT-38) to help characterize a model of vascular

Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Read More »

An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells.

Harle P, Pongratz G, Albrecht J, Tarner IH, Straub RH (2008) An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Arthritis Rheum 58:2347-2355. doi: 10.1002/art.23628 Summary: The sympathetic nervous system can play conflicting roles in collagen-induced arthritis (CIA). CD4+CD25+ T cells can play an immunoregulatory effect in this system depending on the

An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+CD25+ cells. Read More »

Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory.

Wisman L, Sahin G, Maingay M, Leanza G, Kirik D (2008) Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory. J Neurosci 28:7797-7807. doi: 10.1523/JNEUROSCI.1885-08.2008 Summary: Analysis of cholinergic alterations in PD patients may help to understand and treat the nonmotor symptoms of the disease. Usage: Cholinergic neurons in theNBMand the

Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory. Read More »

Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures.

Craig LA, Hong NS, Kopp J, McDonald RJ (2008) Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures. Hippocampus 18(11):1112-1121. doi: 10.1002/hipo.20471 Summary: The loss of cholinergic neurons in the medial septum and seizures are both associated with Alzheimer’s disease. The authors investigated links between these factors using

Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures. Read More »

Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates.

Dotigny F, Ben Amor AY, Burke M, Vaucher E (2008) Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates. Neuroscience 154(4):1607-1618. doi: 10.1016/j.neuroscience.2008.04.030 Summary: Acetylcholine is thought to have a neuromodulatory role in visual processing. After rats were treated with 192-IgG-SAP (Cat. #IT-01, 2 µl of 2.4 µg/µl into the lateral ventricle)

Neuromodulatory role of acetylcholine in visually-induced cortical activation: Behavioral and neuroanatomical correlates. Read More »

Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress.

Radley JJ, Williams B, Sawchenko PE (2008) Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. J Neurosci 28:5806-5816. doi: 10.1523/JNEUROSCI.0552-08.2008 Summary: Hypothalamo-pituitary-adrenal (HPA) responses to emotional stress are in part controlled by the medial prefrontal cortex (mPFC). The locus ceruleus (LC) is also thought to be involved in

Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. Read More »

Amygdala intercalated neurons are required for expression of fear extinction.

Likhtik E, Popa D, Apergis-Schoute J, Fidacaro GA, Pare D (2008) Amygdala intercalated neurons are required for expression of fear extinction. Nature 454(7204):642-645. doi: 10.1038/nature07167 Summary: Scientists have been using fear learning in animals to study human anxiety disorders. In order to investigate the contribution of amygdala plasticity to fear learning, rats received 0.25-µl bilateral

Amygdala intercalated neurons are required for expression of fear extinction. Read More »

Apoptosis or Necrosis?

Q: Do targeted toxin-treated cells die by apoptosis? A: There are, allegedly, two ways for cells to die: by apoptosis or necrosis. According to Fiorenzo Stirpe (the discoverer of saporin), saporin-intoxicated cells die both ways, some by one, others by the other. There is good literature that states that cells die by apoptosis. Saporin and

Apoptosis or Necrosis? Read More »

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