Human Serum Albumin (HSA) is a major constituent of human blood plasma comprising 55% of plasma proteins. Human serum albumin is produced in the liver and plays an important role in maintaining fluid balance in the blood. Affinity-purified Antibody to HSA, rabbit polyclonal,(Cat. #AB-40AP) is affinity-purified with HSA on CnBr-activated Sepharose 4 Fast Flow followed […]
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Saporin is a plant enzyme with N-glycosidase activity that depurinates a specific nucleotide in the ribosomal RNA 28S, thus irreversibly blocking protein synthesis. Affinity-purified Anti-Saporin rabbit polyclonal (Cat. #AB-41AP) is the most recent addition to our line of Saporin antibodies. These antibodies can be used as controls with our Saporin-conjugate immunotoxins, for immunoblotting, and in
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Q: I am planning an experiment to investigate the effects of ablation of spinal NK-1r-expressing cells (using intrathecal injection of SSP-SAP, Cat. #IT-11). In the first part of the experiment I want to destroy the NK-1r-expressing cells before surgical modification. I am unsure how long after injection of SSP-SAP I should carry out the surgery.
Likhtik E (2008) Featured Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in conditioned fear. Targeting Trends 9(4) Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: Likhtik E et al. Amygdala intercalated neurons are required for expression of
Advanced Targeting Systems announces the release of Melanopsin-SAP (Cat. #IT-44), a reagent that specifically eliminates intrinsically photosensitive retinal ganglion cells (ipRGCs) that contain melanopsin. This material is described in Göz et al.[1] and consists of an antibody to an extracellular domain conjugated to saporin. The ipRGCs, with their amazing long processes, have become major players
Targeting Article: Control Circadian Rhythm? Read More »
Contributed by Ekaterina Likhtik Columbia University,New York Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032 Introduction by Douglas Lappi, Ph.D., President/CSO: This quarter’s Cover Article is from Ekaterina Likhtik who reprises her recently published work in Nature 454:642-645. In the News and Views, Sah and Westbrook comment that “Neuronal receptors in these circuits—such as
Murillo-Rodriguez E, Liu M, Blanco-Centurion C, Shiromani PJ (2008) Effects of hypocretin (orexin) neuronal loss on sleep and extracellular adenosine levels in the rat basal forebrain. Eur J Neurosci 28(6):1191-1198. doi: 10.1111/j.1460-9568.2008.06424.x Summary: Adenosine levels in the basal forebrain are thought to regulate the waxing and waning of sleep drive. Rats received bilateral 100-ng injections
Göz D, Studholme K, Lappi DA, Rollag MD, Provencio I, Morin LP (2008) Targeted destruction of photosensitive retinal ganglion cells with a saporin conjugate alters the effects of light on mouse circadian rhythms. PLoS ONE 3(9):e3153. doi: 10.1371/journal.pone.0003153 PMID: 18773079 Summary: Retinal ganglion cells expressing melanopsin photopigment are thought to be involved in non-image forming
Iwatsuki K, Yoshimine T, Kishima H, Aoki M, Yoshimura K, Ishihara M, Ohnishi Y, Lima C (2008) Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats. Neuroreport 19(13):1249-1252. doi: 10.1097/WNR.0b013e328305b70b PMID: 18695502 Related Products: NGFr (192-IgG, p75) Mouse Monoclonal (Cat. #AB-N43)
Mandolesi L, De Bartolo P, Foti F, Gelfo F, Federico F, Leggio MG, Petrosini L (2008) Environmental enrichment provides a cognitive reserve to be spent in the case of brain lesion. J Alzheimers Dis 15:11-28. doi: 10.3233/jad-2008-15102 PMID: 18780964 Summary: The cognitive reserve model suggests individuals can develop resources that reduce the risk of later