1. Home
  2. Knowledge Base
  3. References
  4. The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions.

The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions.

Kalinchuk AV, McCarley RW, Stenberg D, Porkka-Heiskanen T, Basheer R (2008) The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: lessons from 192 IgG-saporin lesions. Neuroscience 157:238-253. doi: 10.1016/j.neuroscience.2008.08.040

Summary: The level of adenosine in the basal forebrain increases during sleep deprivation (SD). The cholinergic system of the basal forebrain is thought to be involved in the control of this process. 0.23 µg of 192-IgG-SAP (Cat. #IT-01) was injected into the horizontal diagonal band/ substantia innominata/ magnocellular preoptic nucleus, or 6 µg into the lateral ventricle of rats. The time course was dependent on the injection site, but eventually the SD-induced increase in adenosine was virtually eliminated.

Related Products: 192-IgG-SAP (Cat. #IT-01)