Author name: Kristen Hartman

Decrease in membrane phospholipid unsaturation induces unfolded protein response.

Ariyama H, Kono N, Matsuda S, Inoue T, Arai H (2010) Decrease in membrane phospholipid unsaturation induces unfolded protein response. J Biol Chem 285(29):22027-22035. doi: 10.1074/jbc.M110.126870 PMID: 20489212 Summary: Properties of the cell membrane can be influenced by the degree of fatty acid unsaturation in membrane phospholipids. Alteration of this unsaturation has been implicated in […]

Decrease in membrane phospholipid unsaturation induces unfolded protein response. Read More »

Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin.

Caudle R, King C, Nolan T, Suckow S, Vierck C, Neubert J (2010) Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin. J Pain 11:838-846. doi: 10.1016/j.jpain.2010.05.007 Objective: To understand central sensitization. Summary: Findings suggest that central sensitization leads to activation of an

Central sensitization in the trigeminal nucleus caudalis produced by a conjugate of substance P and the A subunit of cholera toxin. Read More »

Septohippocampal pathways contribute to system consolidation of a spatial memory: Sequential implication of gabaergic and cholinergic neurons.

Lecourtier L, de Vasconcelos AP, Leroux E, Cosquer B, Geiger K, Lithfous S, Cassel JC (2011) Septohippocampal pathways contribute to system consolidation of a spatial memory: Sequential implication of gabaergic and cholinergic neurons. Hippocampus 21(12):1277-1289. doi: 10.1002/hipo.20837 Summary: Few studies have examined the role of GABAergic septohippocampal projections in memory consolidation. The authors administered 192-IgG-SAP

Septohippocampal pathways contribute to system consolidation of a spatial memory: Sequential implication of gabaergic and cholinergic neurons. Read More »

Targeting Tools: Targeting NGF Receptor-Positive Neurons

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Targeting in mouse: mu p75-SAP (Cat. #IT-16) To create this targeted toxin, we affinity-purified the rabbit polyclonal with the immunogen bound to a solid support, and conjugated the affinity-purified antibody (Cat. #AB-N01AP) to saporin. As can be seen in the cytotoxicity assay below, mu p75-SAP has an EC50 in the picomolar range. This greater potency

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Targeting Tools: CTB-SAP

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CTB-SAP (Cat. #IT-14) is a conjugate between the cell-binding component of cholera toxin (the B chain) and saporin. CTB binds to GM1 (monosialotetrahexosylganglioside), which is present on the surface of different neurons. It has been suggested to be involved in many problems (besides the most famous in the gut: cholera) of neuronal systems: Parkinson’s, motor

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Featured Article: Internalization of basigin-2, a poor prognosis marker, by a monoclonal antibody

Lappi DA, Ancheta LR, Nowak RA (2010) Featured Article: Internalization of basigin-2, a poor prognosis marker, by a monoclonal antibody. Targeting Trends 11(3) PMID: 0 Related Products: Antibody to Basigin (Cat. #AB-42), Anti-Basigin2-SAP (Cat. #IT-54) Read the featured article in Targeting Trends.

Featured Article: Internalization of basigin-2, a poor prognosis marker, by a monoclonal antibody Read More »

Featured Article: Role of cell fate determinants in a model of spinal cord neurotoxic lesion induced by cholera toxin b-saporin

Gulino R, Perciavalle V, Gulisan M (2010) Featured Article: Role of cell fate determinants in a model of spinal cord neurotoxic lesion induced by cholera toxin b-saporin. Targeting Trends 11(3) Related Products: CTB-SAP (Cat. #IT-14) Read the featured article in Targeting Trends. See Also: Gulino R et al. Expression of cell fate determinants and plastic

Featured Article: Role of cell fate determinants in a model of spinal cord neurotoxic lesion induced by cholera toxin b-saporin Read More »

Contribution of limbic norepinephrine to cannabinoid-induced aversion.

Carvalho AF, Reyes AR, Sterling RC, Unterwald E, Van Bockstaele EJ (2010) Contribution of limbic norepinephrine to cannabinoid-induced aversion. Psychopharmacology (Berl) 211(4):479-491. doi: 10.1007/s00213-010-1923-7 Summary: The authors used bilateral injections of anti-DBH-SAP (Cat. #IT-03) into the nucleus accumbens and the bed nucleus of the stria terminalis to investigate the role of neuroepinephrine in cannabinoid-induced aversion

Contribution of limbic norepinephrine to cannabinoid-induced aversion. Read More »

Targeting Article: Poster at American Association for Cancer Research Meeting

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At this year’s AACR meeting, Leonardo Ancheta, scientist and Product Manager from ATS, presented a poster on our new monoclonal antibody to Basigin-2 (Cat. #AB-42). The poster describes our work with the antibody and the immunotoxin made from it (Cat. #IT-54). Basigin-2 (EMMPRIN, CD147) is widely expressed on the surface of numerous tumor types and

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Cover Article: Role of Cell Fate Determinants in a Model of Spinal Cord Neurotoxic Lesion Induced by Cholera Toxin B-Saporin

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Contributed by Rosario Gulino, Vincenzo Perciavalle and Massimo Gulisan Dept of Physiological Sciences, Univ of Catania, Viale Andrea Doria, 6-I95125 Catania ITALY A promising approach for central nervous system (CNS) repair consists in the activation of endogenous neural precursor cells (NPCs), but this process is less efficient in the spinal cord (SC) following a spinal

Cover Article: Role of Cell Fate Determinants in a Model of Spinal Cord Neurotoxic Lesion Induced by Cholera Toxin B-Saporin Read More »

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