Author name: Kristen Hartman

Featured Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn

Sorkin LS, Choi JI, Koehrn FJ (2011) Featured Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn. Targeting Trends 12(2) Related Products: SSP-SAP (Cat. #IT-11) Read the featured article in Targeting Trends. See Also: Sorkin LS et al. Carageenan evoked P-Akt in deep […]

Featured Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn Read More »

Targeting Article: Basigin-2 (EMMPRIN), a Prognostic Marker, is a Dynamic Portal of Entry into Cancer Cells

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by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for

Targeting Article: Basigin-2 (EMMPRIN), a Prognostic Marker, is a Dynamic Portal of Entry into Cancer Cells Read More »

Cover Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn

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Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed

Cover Article: Carrageenan evoked P-Akt in deep dorsal horn neurons is prevented by loss of neurokinin1 positive neurons in superficial dorsal horn Read More »

Reassessment of the structural basis of the ascending arousal system.

Fuller P, Sherman D, Pedersen NP, Saper CB, Lu J (2011) Reassessment of the structural basis of the ascending arousal system. J Comp Neurol 519(5):933-956. doi: 10.1002/cne.22559 Summary: Traditional thought has been that electroencephalogram activity is mainly generated by the thalamo-cortical system. In this work the authors investigated the effects of basal forebrain lesions on

Reassessment of the structural basis of the ascending arousal system. Read More »

Cholinergic depletion in the nucleus accumbens: Effects on amphetamine response and sensorimotor gating.

Laplante F, Lappi DA, Sullivan RM (2011) Cholinergic depletion in the nucleus accumbens: Effects on amphetamine response and sensorimotor gating. Prog Neuropsychopharmacol Biol Psychiatry 35(2):501-509. doi: 10.1016/j.pnpbp.2010.12.005 Summary: Disruption of dopamine and acetylcholine balance in the striatum may play a role in conditions such as Parkinson’s and schizophrenia. In this work the authors lesioned cholinergic

Cholinergic depletion in the nucleus accumbens: Effects on amphetamine response and sensorimotor gating. Read More »

Selective formation of covalent protein heterodimers with an unnatural amino acid.

Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Smider VV, Schultz PG (2011) Selective formation of covalent protein heterodimers with an unnatural amino acid. Chem Biol 18(3):299-303. doi: 10.1016/j.chembiol.2011.01.006 PMID: 21439474 Summary: This work demonstrates the creation of a variety of constructs containing specific defined conjugation sites. One use for these molecules is

Selective formation of covalent protein heterodimers with an unnatural amino acid. Read More »

Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface.

Chung JS, Shiue LH, Duvic M, Pandya A, Cruz PDJ, Ariizumi K (2011) Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. Blood 117(12):3382-3390. doi: 10.1182/blood-2010-08-302034 Summary: Syndecan-4 (SD-4) is a transmembrane heparan sulfate proteoglycan. The Sézary syndrome (SS) subset

Sezary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. Read More »

Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin.

Hernandez-Melesio MA, Gonzalez-Esquivel D, Ortiz-Plata A, Sanchez-Mendoza A, Sanchez-Garcia A, Alcaraz-Zubeldia M, Rios C, Perez-Severiano F (2011) Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin. Neurosci Lett 491(2):133-137. doi: 10.1016/j.neulet.2011.01.023 Summary: Nitric oxide (NO) is required for the survival of cholinergic neurons in the basal forebrain. Delivery

Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin. Read More »

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke.

Heldmann U, Mine Y, Kokaia Z, Ekdahl CT, Lindvall O (2011) Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Exp Neurol 229(2):391-398. doi: 10.1016/j.expneurol.2011.03.005 Summary: One result of ischemic stroke is migration of newly formed neuroblasts into the injured area from the subventricular zone (SVZ). The

Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Read More »

The effects of intrathecal and systemic gabapentin on spinal substance P release.

Takasusuki T, Yaksh TL (2011) The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg 112(4):971-976. doi: 10.1213/ANE.0b013e31820f2a16 PMID: 21385982 Summary: Intrathecal or systemically-administered gabapentin is an antihyperalgesic. Given that gabapentin binds a voltage-sensitive calcium channel and that some of these channels regulate substance P (SP) release, the authors investigated whether

The effects of intrathecal and systemic gabapentin on spinal substance P release. Read More »

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