Author name: Kristen Hartman

Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat.

Ocampo-Garces A, Ibanez F, Perdomo G, Torrealba F (2011) Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat. J Sleep Res 20:3-11. doi: 10.1111/j.1365-2869.2010.00864.x Summary: Photic masking occurs when photic input to the retina interferes with REM sleep. Rats that received 200 ng of orexin-SAP (Cat. […]

Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat. Read More »

Human monoclonal antibodies to Sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity.

Sawada R, Sun SM, Wu X, Hong F, Ragupathi G, Livingston PO, Scholz WW (2011) Human monoclonal antibodies to Sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity. Clin Cancer Res 17(5):1024-1032. doi: 10.1158/1078-0432.CCR-10-2640 Summary: In this work the authors investigated the use of a carbohydrate antigen, sialyl-Lewisa (CA19.9), as a target for cancer therapeutics.

Human monoclonal antibodies to Sialyl-Lewisa (CA19.9) with potent CDC, ADCC, and antitumor activity. Read More »

TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex

Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, Reichardt LF (2011) TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. J Neurosci 31(8):2769-2780. doi: 10.1523/JNEUROSCI.4991-10.2011 PMID: 21414899 Summary: In this work the authors investigated the role of TrkB in GABAergic inhibitory synapses in the

TrkB (Tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex Read More »

Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult.

Paban V, Chambon C, Farioli F, Alescio-Lautier B (2011) Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult. Neurobiol Learn Mem 95(4):441-452. doi: 10.1016/j.nlm.2011.02.005 Summary: Microarray technology was used to screen gene expression in a model of attention and memory deficit. Rats received bilateral injections of 192-IgG-SAP (Cat. #IT-01) into

Gene regulation in the rat prefrontal cortex after learning with or without cholinergic insult. Read More »

The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis.

Rennie K, Frechette M, Pappas BA (2011) The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis. Brain Res 1373(10):79-90. doi: 10.1016/j.brainres.2010.11.091 Summary: Intraventricular injections of 192-IgG-SAP (Cat. #IT-01) have been shown to reduce the number of cells expressing a marker for immature neuroblasts in the dentate gyrus, as well as possibly impairing the

The effects of neonatal forebrain cholinergic lesion on adult hippocampal neurogenesis. Read More »

Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding.

Li AJ, Wang Q, Ritter S (2011) Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding. Diabetes 60(2):436-442. doi: 10.2337/db10-0352 Summary: Catecholamine neurons innervating the medial hypothalamus are involved in the control of glucoprivic feeding as well as other responses to glucose deficit. Rats received bilateral 82-ng injections of anti-DBH-SAP (Cat. #IT-03) into the paraventricular

Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding. Read More »

Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons.

Gibbs RB, Chipman AM, Nelson D (2011) Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons. Horm Behav 59(4):503-511. doi: 10.1016/j.yhbeh.2011.01.011 Summary: Among the beneficial effects of estrogen on the brain are improved cognitive performance and prevention of age-related cognitive decline. These positive

Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons. Read More »

Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics.

Leung LS, Petropoulos S, Shen B, Luo T, Herrick I, Rajakumar N, Ma J (2011) Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics. Exp Neurol 228(2):259-269. doi: 10.1016/j.expneurol.2011.01.019 Summary: Consciousness and response to general anesthesia have been linked to acetylcholine in the brain. The authors treated rats with 150-ng bilateral injections

Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics. Read More »

PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression.

Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL (2011) PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. J Neurosci 31(4):1292-1301. doi: 10.1523/JNEUROSCI.4611-10.2011 PMID: 21273414 Summary: In order to identify the neurons involved with respiratory depression due to administration of opioids, some neuro- transmission networks in the preBotzinger complex were locally

PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. Read More »

Generation of human melanocytes from induced pluripotent stem cells

Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y (2011) Generation of human melanocytes from induced pluripotent stem cells. PLoS One 6(1):e16182. doi: 10.1371/journal.pone.0016182 PMID: 21249204 Summary: For immunocytochemistry, cells were fixed with PBS containing 4% PFA for 20 min at room

Generation of human melanocytes from induced pluripotent stem cells Read More »

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