Gelfo F, Tirassa P, De Bartolo P, Caltagirone C, Petrosini L, Angelucci F (2011) Brain and serum levels of nerve growth factor in a rat model of Alzheimer’s disease. J Alzheimers Dis 25(2):213-217. doi: 10.3233/JAD-2011-110047 PMID: 21368378
Objective: Using nerve growth factor (NGF) as a marker of disease progression in Alzheimer’s disease using cholinergic depletion animal models.
Summary: Different Alzheimer’s disease stages show different levels of NGF present in the brain. 192-IgG-SAP was used to deplete the cholinergic neurons in rats the same way as Alzheimer’s does in humans. NGF levels were measured by ELISA 3, 7, and 15 days after injection and a disease progression correlation with NGF was constructed.
Usage: 2 µL/side of immunotoxin 192 IgG-SAP (IT-01) diluted in PBS (2 µg/µL) was bilaterally injected into lateral ventricles (rate: 1 µL/min).
Related Products: 192-IgG-SAP (Cat. #IT-01)