St Peters M, Demeter E, Lustig C, Bruno JP, Sarter M (2011) Enhanced control of attention by stimulating mesolimbic-corticopetal cholinergic circuitry. J Neurosci 31(26):9760-9771. doi: 10.1523/JNEUROSCI.1902-11.2011
Summary: Motivation and attention interact to preserve cognitive performance under challenging conditions. In order to better define the circuitry connecting these two processes, the authors lesioned the prefrontal cortex (200 ng of 192-IgG-SAP, Cat. #IT-01) and the posterior parietal cortex (280 ng of 192-IgG-SAP). Mouse IgG-SAP (Cat. #IT-18) was used as a control. The data indicate that cholinergic projections to the cortex modulate detection of clues and filtering of distractors during attentional tasks, accentuating cognitive control.