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A central role for BDNF and Sonic Hedgehog in controlling synaptic plasticity in motoneuron-depleted spinal cord

Gulino R, Gulisano M (2011) A central role for BDNF and Sonic Hedgehog in controlling synaptic plasticity in motoneuron-depleted spinal cord. IBRO 2011 Abstracts International Brain Research Organization, Florence, Italy.

Summary: Here, we measured the expression levels of several proteins involved in synaptic plasticity and motoneuronal function (ChAT, Synapsin-I, Shh, Notch-1, AMPA receptor subunits, NMDA receptor and BDNF) in a mouse SC lesion model obtained by intramuscular injection of Cholera toxin-B-saporin, which selectively kills motoneurons

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