Author name: Kristen Hartman

Featured Article: A pivotal role of lumbar spinothalamic cells in regulation of ejaculation via intraspinal connections

Coolen LM (2012) Featured Article: A pivotal role of lumbar spinothalamic cells in regulation of ejaculation via intraspinal connections. Targeting Trends 13(3) Related Products: SSP-SAP (Cat. #IT-11), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: Staudt MD et al. A Pivotal Role of Lumbar Spinothalamic Cells in the Regulation of Ejaculation […]

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Cover Article: A pivotal role of lumbar spinothalamic cells in regulation of ejaculation via intraspinal connections

Contributed by Lique M. Coolen, University of Michigan Introduction from Dr. Lappi: An article by Lique Coolen’s group[5] was the 1000th article in PubMed in response to the search word ‘saporin.’ Dr. Coolen has graciously agreed to describe the latest in her fascinating work. Male sexual behavior consists of many different aspects, with ejaculation being

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Peptidergic Edinger-Westphal neurons and the energy-dependent stress response

Xu L, Scheenen WJ, Roubos EW, Kozicz T (2012) Peptidergic Edinger-Westphal neurons and the energy-dependent stress response. Gen Comp Endocrinol 177(3):296-304. doi: 10.1016/j.ygcen.2011.11.039 Objective: This study investigates the role of the midbrain Edinger–Westphal centrally projecting neuron population (EWcp; synonym: non-preganglionic Edinger–Westphal nucleus) in the energy-dependent stress adaptation response. Summary: The current data indicates that the

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Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats.

Sikandar S, Bannister K, Dickenson AH (2012) Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats. Neurosci Lett 519(1):31-36. doi: 10.1016/j.neulet.2012.05.009 Summary: Neurons in the rostral ventromedial medulla (RVM) are classified as ON, OFF, or NEUTRAL based on firing patterns in response to noxious somatic stimulation. ON cells

Brainstem facilitations and descending serotonergic controls contribute to visceral nociception but not pregabalin analgesia in rats. Read More »

A nociceptive signaling role for neuromedin B.

Mishra SK, Holzman S, Hoon MA (2012) A nociceptive signaling role for neuromedin B. J Neurosci 32(25):8686-8695. doi: 10.1523/JNEUROSCI.1533-12.2012 Summary: Previous work suggests that neuromedin B (NMB) is involved in nociception. Direct injection of the peptide causes nociceptive sensitization, while NMB antagonists attenuate sensitization in reponse to nerve stimulation with mustard oil. Specific subsets of

A nociceptive signaling role for neuromedin B. Read More »

Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells.

Tai SK, Leung LS (2012) Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells. Behav Brain Res 232(1):174-182. doi: 10.1016/j.bbr.2012.04.013 Summary: It is known that vestibular stimulation induces acetylcholine release in the hippocampus. The authors hypothesized that this stimulation enhances long-term potentiation (LTP) in CA1 and depends on the activation of septohippocampal

Vestibular stimulation enhances hippocampal long-term potentiation via activation of cholinergic septohippocampal cells. Read More »

C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats.

Abbott SB, Kanbar R, Bochorishvili G, Coates MB, Stornetta RL, Guyenet PG (2012) C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. J Physiol 590(12):2897-2915. doi: 10.1113/jphysiol.2012.232157 Summary: C1 neurons are known to activate sympathetic tone and stimulate the hypothalamic-pituitary-adrenal axis. C1 activation is also reported to inhibit locus

C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. Read More »

Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms.

Li AJ, Wiater MF, Oostrom MT, Smith BR, Wang Q, Dinh TT, Roberts BL, Jansen HT, Ritter S (2012) Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. Am J Physiol Regul Integr Comp Physiol 302(11):R1313-26. doi: 10.1152/ajpregu.00086.2012 Summary: It is clear that the arcuate nucleus (Arc) plays an important role in the

Leptin-sensitive neurons in the arcuate nuclei contribute to endogenous feeding rhythms. Read More »

Effects of noradrenergic alpha-2 receptor antagonism or noradrenergic lesions in the ventral bed nucleus of the stria terminalis and medial preoptic area on maternal care in female rats.

Smith CD, Holschbach MA, Olsewicz J, Lonstein JS (2012) Effects of noradrenergic alpha-2 receptor antagonism or noradrenergic lesions in the ventral bed nucleus of the stria terminalis and medial preoptic area on maternal care in female rats. Psychopharmacology (Berl) 224(2):263-276. doi: 10.1007/s00213-012-2749-2 Summary: The authors investigated the function of norepinephrine in mothering. Lesioned animals received

Effects of noradrenergic alpha-2 receptor antagonism or noradrenergic lesions in the ventral bed nucleus of the stria terminalis and medial preoptic area on maternal care in female rats. Read More »

A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats.

Pedrino GR, Freiria-Oliveira AH, Almeida Colombari DS, Rosa DA, Cravo SL (2012) A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats. PLoS One 7(5):e37587. doi: 10.1371/journal.pone.0037587 Summary: It is thought that renal sympathetic nerve activity is a key component of the response to acute or chronic elevated concentrations of saline in the blood

A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats. Read More »

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