Author name: Kristen Hartman

Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus.

Kanju PM, Parameshwaran K, Sims-Robinson C, Uthayathas S, Josephson EM, Rajakumar N, Dhanasekaran M, Suppiramaniam V (2012) Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PLoS One 7(2):e31073. doi: 10.1371/journal.pone.0031073 Summary: Long term potentiation (LTP) is dependent on excitatory neurotransmission in the hippocampus, which […]

Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. Read More »

Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice.

Han N, Zu JY, Chai J (2012) Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice. Clin Exp Dermatol 37(3):290-295. doi: 10.1111/j.1365-2230.2011.04314.x Summary: The authors administered 400 ng of Bombesin-SAP (Cat. #IT-40) to the lumbar spinal subarachnoid space of rats and evaluated the distribution of Fos-positive cells in the dorsal horn

Spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice. Read More »

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice

Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF (2012) Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology 142:1195-1205.e1196. doi: 10.1053/j.gastro.2012.02.006 Objective: To investigate the existence of

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice Read More »

Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug.

Selbo PK, Weyergang A, Eng MS, Bostad M, Maelandsmo GM, Hogset A, Berg K (2012) Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug. J Control Release 159(2):197-203. doi: 10.1016/j.jconrel.2012.02.003 Summary: Many anti-cancer drugs are substrates of the

Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug. Read More »

Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks.

Antonucci F, Alpár A, Kacza J, Caleo M, Verderio C, Giani A, Martens H, Chaudhry FA, Allegra M, Grosche J, Michalski D, Erck C, Hoffmann A, Harkany T, Matteoli M, Härtig W (2012) Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks. J Neurosci 32(6):1989-2001. doi: 10.1523/JNEUROSCI.2720-11.2012 Related Products: Anti-vGAT-SAP (Cat. #IT-71)

Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks. Read More »

Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias.

Gibbons DD, Southerland EM, Hoover DB, Beaumont E, Armour JA, Ardell JL (2012) Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol 302(3):R357-R364. doi: 10.1152/ajpregu.00535.2011 PMID: 22088304 Summary: Cardiac arrhythmias can be generated by excessive activation of specific inputs to the intrinsic cardiac nervous system. The

Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias. Read More »

Vector-mediated gene delivery to model striatal interneuron loss in sever tourette syndrome

Kobets AJ (2012) Vector-mediated gene delivery to model striatal interneuron loss in sever tourette syndrome. Yale Univ School and Medicine Thesis. Objective: Develop a viral-mediated gene delivery technique to selectively ablate striatal interneurons in mice to model the pathophysiology of Tourette syndrome (TS). Summary: The loss of striatal interneurons was speculated to play a role

Vector-mediated gene delivery to model striatal interneuron loss in sever tourette syndrome Read More »

Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn.

Choi JI, Koehrn FJ, Sorkin LS (2012) Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Mol Pain 8(1):4. doi: 10.1186/1744-8069-8-4 PMID: 22243518 Summary: In this work the authors administered 100 ng SSP-SAP (Cat. #IT-11) into the intrathecal space of rats (saporin, Cat. #PR-01, was used as a

Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn. Read More »

Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex.

Tolner EA, Sheikh A, Yukin AY, Kaila K, Kanold PO (2012) Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. J Neurosci 32(2):692-702. doi: 10.1523/JNEUROSCI.1538-11.2012 Summary: Immature cortices in both human and rat have spontaneous activity associated with the maturation of cortical synapses and neuronal circuits. In order to investigate

Subplate neurons promote spindle bursts and thalamocortical patterning in the neonatal rat somatosensory cortex. Read More »

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