Q: We are interested in having a custom conjugation of saporin and our antibody. Do you remove unconjugated antibody from the final material you send us? A: We do remove the unconjugated antibody and saporin from the final product that we send to you. And perhaps to answer a question you may not be asking, […]
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Q: I’d like to know which of your products are the pan-neural targeting toxins? I need an agent to kill all nerves in tissue preps. A: OX7-SAP (Cat. #IT-02) should be perfect for this application. We recommend you examine your neurons with OX-7 antibody to see if they are positive. The only complication would be
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Ye Y, Dang D, Viet CT, Dolan JC, Schmidt BL (2012) Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity. J Pain 13(6):524-531. doi: 10.1016/j.jpain.2012.01.006 Summary: DOR (δ opioid receptor) agonists produce minimal side effects and do not lead to tolerance, making them potential alternatives to the widely used μ opioid receptor agonists. Utilizing the fact
Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity. Read More »
Rance NE, Mittelman-Smith MA, Krajewski-Hall SJ (2012) Featured Article: Use of a novel saporin conjugate (NK3-SAP) to study the function of neurokinin 3 receptor (NK3r)-expressing kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the rat arcuate nucleus. Targeting Trends 13(2) Related Products: NKB-SAP (Cat. #IT-63), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends. See Also: Mittelman-Smith
Kruger HS, Hanganu-Opatz IL (2013) Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development. Dev Psychobiol 55(3):294-308. doi: 10.1002/dev.21029 Summary: The architecture of the cerebral cortex is dependent on cholinergic innervations for proper maturation and network assembly. The authors administered 0.1 μg of 192-IgG-SAP (Cat. #IT-01) to
Contributed by Naomi E. Rance, Melinda. A. Mittelman-Smith and Sally J. Krajewski-Hall Department of Pathology, University of Arizona College of Medicine This year, our two posters shared the ATS Poster of the Year Award at the Society for Neuroscience Meeting. These posters documented the use of NK3-SAP, a custom conjugate of saporin (Cat. #IT-63) with
Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein JL, Reichardt LF, Parada LF (2012) TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci 32(12):4065-4079. doi: 10.1523/JNEUROSCI.6314-11.2012 PMID: 22442072 Summary: The authors created a conditional trkA knockout mouse line. Anti-trkA (Cat. #AB-N03) was used for immunohistochemistry (1:1000) and western
Lin LH, Nitschke Dragon D, Talman WT (2012) Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat. J Chem Neuroanat 43(2):141-148. doi: 10.1016/j.jchemneu.2012.02.001 Summary: Loss of substance P receptor (SPR)-expressing neurons in the nucleus tractus solitarii (NTS) results in reduced baroreflex
Lowrance S, Matchynski J, Rossignol J, Dekorver N, Sandstrom M, Dunbar G (2012) CXB-909 attenuates cognitive deficits in the mu-p-75 saporin mouse model of Alzheimer’s disease. Neuroscience & Medicine 3(1):65-68. doi: 10.4236/nm.2012.31010 Summary: CXB-909 is a small molecule NGF amplifier that has been shown to enhance neurite outgrowth in various neuronal cell lines. This type
Hawryluk JM, Ferrari LL, Keating SA, Arrigoni E (2012) Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons. J Neurophysiol 107(10):2769-2781. doi: 10.1152/jn.00528.2011 PMID: 22357797 Summary: Using patch-clamp recordings from mouse brain slices the authors demonstrate that adenosine not only directly inhibits cholinergic neurons in the basal forebrain, it also reduces excitatory inputs to these
Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons. Read More »