Author name: Kristen Hartman

Lamina I NK1 expressing projection neurones are functional in early postnatal rats and contribute to the setting up of adult mechanical sensory thresholds.

Man SH, Geranton SM, Hunt SP (2012) Lamina I NK1 expressing projection neurones are functional in early postnatal rats and contribute to the setting up of adult mechanical sensory thresholds. Mol Pain 8(1):35. doi: 10.1186/1744-8069-8-35 Summary: Projections from lamina I neurons regulate mechanical and thermal sensitivity due to injury. Little is known about how these […]

Lamina I NK1 expressing projection neurones are functional in early postnatal rats and contribute to the setting up of adult mechanical sensory thresholds. Read More »

Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain.

Taylor AM, Osikowicz M, Ribeiro-da-Silva A (2012) Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain. Pain 153(6):1311-1319. doi: 10.1016/j.pain.2012.03.023 Summary: The authors used IB4-SAP (Cat. #IT-10; 3.2 μg injected into the mental nerve) to eliminate C-fibers in the lower lip of rats to see if this was enough

Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain. Read More »

c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.

Hu J, Huang T, Li T, Guo Z, Cheng L (2012) c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. J Neurosci 32(16):5362-5373. doi: 10.1523/JNEUROSCI.6239-11.2012 PMID: 22514301 Summary: The molecular mechanisms responsible for development of laminae III/IV neurons are not yet well understood. In this work the

c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. Read More »

Arcuate kisspeptin/neurokinin b/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.

Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, Lai J, Ciofi P, McMullen NT, Rance NE ( 2012 ) Arcuate kisspeptin/neurokinin b/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 153(6):2800-2812 . doi: 10.1210/en.2012-1045 Related Products: NKB-SAP (Cat. #IT-63), Blank-SAP (Cat. #IT-21) Read the featured article in Targeting Trends.

Arcuate kisspeptin/neurokinin b/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Read More »

Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain noncholinergic neurons.

Ovsepian SV, Dolly JO, Zaborszky L (2012) Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain noncholinergic neurons. J Neurophysiol 108(2):406-418. doi: 10.1152/jn.00642.2011 PMID: 22496531 Summary: The voltage modulation functions of the basal forebrain have commonly been associated with cholinergic cells. More recent work has suggested that noncholinergic cells have an

Intrinsic voltage dynamics govern the diversity of spontaneous firing profiles in basal forebrain noncholinergic neurons. Read More »

Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat.

Talman WT, Dragon DN, Jones SY, Moore SA, Lin LH (2012) Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat. Cell Mol Neurobiol 32(7):1119-1126. doi: 10.1007/s10571-012-9835-1 Summary: Previous work has shown that elimination of neurons expressing the neurokinin-1 receptor (NK1r) from the nucleus tractus solitarii (NTS) causes

Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat. Read More »

Targeting Tools: Anti-RFP

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Red fluorescent protein (RFP) is derived from Discosoma sea anemone. This antibody (Anti-RFP, Cat. #AB-332) recognizes native and denatured forms of RFP. The antigen for this antibody is present in all of these fluorescent molecules: RFP, tag-RFP, turbo-RFP, DeRed, mCherry, and mOrange. The epitope for the antibody is part of the RFP N-terminal sequence. RFP

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Targeting Tools: NK3-SAP

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An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NK3-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several

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Targeting Tools: Chick-ZAP

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Chick-ZAP is the most recent in our line of Secondary Conjugates. It is a chemical conjugate of affinity-purified rabbit anti-chicken IgY and the ribosome-inactivating protein, saporin. The conjugate will target and eliminate cells that recognize your primary antibody. This reagent can be utilized for screening chicken IgY antibodies for internalization and/or their suitability to make

Targeting Tools: Chick-ZAP Read More »

Reducing Agent in Media

Q:  We will be using your chick-ZAP secondary conjugate (Cat. #IT-62) and noticed that in your protocol you mention not to use a reducing agent in your media. Our normal growth media contains beta mercaptoethanol at 100 μM. Will this be a problem? A: Officially, we would recommend allowing the cells to acclimate to media

Reducing Agent in Media Read More »

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