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  4. Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum.

Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum.

Huang TY, Lin LS, Cho KC, Chen SJ, Kuo YM, Yu L, Wu FS, Chuang JI, Chen HI, Jen CJ (2012) Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. J Appl Physiol 113(6):889-895. doi: 10.1152/japplphysiol.01363.2011

Summary: It is known that exercise can improve motor performance, but the cellular changes that occur in the cerebellum in response to exercise are not understood. Rats were subject to exercise training and a rotarod test was used to evaluate performance. After training some animals were given a 2 μg injection of OX7-SAP (Cat. #IT-02) into the lateral ventricle. In sedentary rats OX7-SAP administration reduced rotarod performance as well as eliminated 60% of Purkinjie cells. Rats given exercise training exhibited much milder injury in the cerebellum as a result of the lesion and maintained a higher level of rotarod performance than the sedentary group.

Related Products: OX7-SAP (Cat. #IT-02)