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  4. C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats.

C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats.

Abbott SB, Kanbar R, Bochorishvili G, Coates MB, Stornetta RL, Guyenet PG (2012) C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. J Physiol 590(12):2897-2915. doi: 10.1113/jphysiol.2012.232157

Summary: C1 neurons are known to activate sympathetic tone and stimulate the hypothalamic-pituitary-adrenal axis. C1 activation is also reported to inhibit locus coeruleus (LC) neurons. Rats received 0.6 ng of SSP-SAP (Cat. #IT-11) injected under the caudal edge of the facial motor nucleus to destroy the retrotrapezoid nucleus, increasing the proportion of C1 ChR2-expressing neurons. Stimulation of C1 neurons resulted in activation of noradrenergic neurons that are involved in hypoxia and hypotension.

Related Products: SSP-SAP (Cat. #IT-11)