Author name: Kristen Hartman

Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum.

Cai L, Gibbs RB, Johnson DA (2012) Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum. Neurosci Lett 506(2):261-265. doi: 10.1016/j.neulet.2011.11.019 Summary: This work examined object recognition and object location recognition as specific components of memory. Rats received 0.22 μg of 192-IgG-SAP (Cat. #IT-01) infused into the […]

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Targeting Tools: Anti-mGluR2

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There are eight known metabotropic glutamate receptors (mGluR) playing diverse roles in brain function and pathology. They are 7-transmembrane domain receptors involved in learning, memory, anxiety, synaptic plasticity, and pain perception. The ligand for these receptors is glutamate, which functions as an excitatory neurotransmitter. mGluR2 is involved in the inhibition of the cAMP cascade. Potentiation

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Featured Article: Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry

St Peters M, Sarter M (2012) Featured Article: Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry. Targeting Trends 13(1) Related Products: 192-IgG-SAP (Cat. #IT-01), Mouse IgG-SAP (Cat. #IT-18) Read the featured article in Targeting Trends. See Also: St Peters M et al. Enhanced control of attention by stimulating mesolimbic-corticopetal cholinergic circuitry. J Neurosci 31(26):9760-9771,

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Cover Article: Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry

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Contributed by Megan St. Peters and Martin Sarter Departments of Psychology at Ferrum College, Ferrum, VA and University of Michigan, Ann Arbor, MI Increasing attentional “effort” as a result of challenging circumstances, and as a function to maintain or recover attentional performance, is pervasive in our daily lives.[1] Attentional effort is more than a function

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Control of the central chemoreflex by A5 noradrenergic neurons in rats.

Taxini CL, Takakura AC, Gargaglioni LH, Moreira TS (2011) Control of the central chemoreflex by A5 noradrenergic neurons in rats. Neuroscience 199:177-186. doi: 10.1016/j.neuroscience.2011.09.068 Summary: The A5 group of noradrenergic neurons in the ventrolateral pons is involved in the control of sympathetic and respiratory networks. Using anti-DBH-SAP (Cat. #IT-03) the authors eliminated TH+ neurons in

Control of the central chemoreflex by A5 noradrenergic neurons in rats. Read More »

IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat.

Alvarez P, Gear RW, Green PG, Levine JD (2012) IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat. Exp Neurol 233(2):859-865. doi: 10.1016/j.expneurol.2011.12.019 Summary: In order to clarify the roles of isolectin B4-positive and IB4-negative nociceptors in inflammatory and ergonomic muscle pain, the authors administered 3.2 µg of IB4-SAP (Cat. #IT-10) into the

IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat. Read More »

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