Lacerda CM, Kisiday J, Johnson B, Orton EC (2012) Local serotonin mediates cyclic strain-induced phenotype transformation, matrix degradation, and glycosaminoglycan synthesis in cultured sheep mitral valves. Am J Physiol Heart Circ Physiol 302(10):H1983-90. doi: 10.1152/ajpheart.00987.2011 PMID: 22345569
Summary: Calcific aortic valve disease and myxomatous mitral valve disease (MMVD) are the most commonly seen degenerative heart valve diseases. Exogenous serotonin has been shown to induce valvulopathy, but current opinion regards serotoninergic and degenerative valvulopathies as unrelated. This work investigated the relationship between serotonin synthesis and strain-induced MMVD in cultured sheep mitral valve leaflets. Anti-SERT (Cat. #AB-N09) was used in immunoblotting experiments. The results demonstrate local serotonin synthesis by mitral valves, modulation of this synthesis by tensile loading, and inhibition of serotonin results in the reduction of strain-mediated protein expression.
Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09)