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Peptidergic Edinger-Westphal neurons and the energy-dependent stress response

Xu L, Scheenen WJ, Roubos EW, Kozicz T (2012) Peptidergic Edinger-Westphal neurons and the energy-dependent stress response. Gen Comp Endocrinol 177(3):296-304. doi: 10.1016/j.ygcen.2011.11.039

Objective: This study investigates the role of the midbrain Edinger–Westphal centrally projecting neuron population (EWcp; synonym: non-preganglionic Edinger–Westphal nucleus) in the energy-dependent stress adaptation response.

Summary: The current data indicates that the EWcp receives information about stressors and peripheral metabolic status, and responds to this information by generating various neuropeptide messengers.

Usage: Leptin-SAP was injected into the EWcp, to kill Leptin receptor-positive neurons. With this approach ~50% of the Ucn1/CART neurons of the EWcp were lost, and the weights of both brown and white adipose tissue significantly increased.

Related Products: Leptin-SAP (Cat. #IT-47)