Author name: Kristen Hartman

Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease.

Shin E, Rogers J, Devoto P, Björklund A, Carta M (2014) Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. Exp Neurol 257:25-38. doi: 10.1016/j.expneurol.2014.04.011 Summary: Although Parkinson’s disease is usually associated with loss of dopaminergic neurons in the substantia nigra, post-mortem studies have shown […]

Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson’s disease. Read More »

The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses.

Jokiaho A, Donovan C, Watts A (2014) The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses. Diabetes 63:2854-2865. doi: 10.2337/db13-1753 Summary: Different sets of glucosensors detect insulin-induced hypoglycemia depending on the onset rate. This detection controls the activation of sympathoadrenal counterregulatory responses (CRRs). Slow onset

The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses. Read More »

Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats.

Arias-Carrión O, Murillo-Rodríguez E (2014) Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. PLoS One 9:e95342. doi: 10.1371/journal.pone.0095342 Summary: In this work the authors examined the effect of orexin cell grafts into the lateral hypothalamus (LH) on narcoleptic-like sleep behavior. Rats received bilateral 490-ng injections of orexin-SAP* into the LH. 21 days

Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. Read More »

Targeting Tools: Top Twenty

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Top Five Targeted Toxins #1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) targets cells expressing rat p75NTR #2. Anti-DBH-SAP (Cat. #IT-03) targets cells expressing rat dopamine beta-hydroxylase (DBH) #3. mu p75-SAP (Cat. #IT-16) targets cells expressing mouse p75NTR #4. IB4-SAP (Cat. #IT-10) targets cells expressing α-D-galactopyranoside residues #5. Mac-1-SAP mouse/human (Cat. #IT-06) targets cells expressing mouse / human

Targeting Tools: Top Twenty Read More »

Targeting Stars: SFN Poster Winners

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2000 – Robert Sloviter and Jennifer Martin used SSP-SAP (Cat# IT-11) 2001 –  Mary Ann Greco used Orexin-SAP 2002 – Lique Coolen and William Truitt used SSP-SAP (Cat# IT-11) 2003 – Jill McGaughy used 192-IgG-Saporin (Cat# IT-01) 2004 – Michelle Pearson used IB4-SAP (Cat# IT-10) 2005 – W.Zhang used Dermorphin-SAP (Cat. #IT-12) and CCK-SAP (Cat. #IT-31) 2006 – Neelima Chauhan used mu

Targeting Stars: SFN Poster Winners Read More »

Cover Article: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994)

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Advanced Targeting Systems’ first product, 192-IgG-SAP, answered a long-sought request from behavioral neuroscientists: a neurotoxin for the cholinergic neurons of the basal forebrain. Over the years it has become the classic in the field and has changed the way that we think about those neurons and their role in learning and memory. Substance P-saporin (SP-SAP)

Cover Article: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994) Read More »

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells

Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS (2014) p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells. J Biol Chem 289(12):8067-8085. doi: 10.1074/jbc.M113.513762 PMID:

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells Read More »

Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat.

Alvarez P, Green P, Levine J (2014) Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat. Pain 155:1161-1167. doi: 10.1016/j.pain.2014.03.004 Summary: In order to better understand where monocyte chemoattractant protein 1 (MCP-1) fits in the chronic pain landscape the authors performed a series of experiments using antisense and mismatch

Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat. Read More »

TrkA in vivo function is negatively regulated by ubiquitination.

Kiris E, Wang T, Yanpallewar S, Dorsey S, Becker J, Bavari S, Palko M, Coppola V, Tessarollo L (2014) TrkA in vivo function is negatively regulated by ubiquitination. J Neurosci 34:4090-4098. doi: 10.1523/JNEUROSCI.4294-13.2014 PMID: 24623787 Summary: The high affinity nerve growth factor receptor, trkA, plays an intrinsic role in the regulation of various aspects of

TrkA in vivo function is negatively regulated by ubiquitination. Read More »

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