Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats.

Arias-Carrión O, Murillo-Rodríguez E (2014) Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. PLoS One 9:e95342. doi: 10.1371/journal.pone.0095342

Summary: In this work the authors examined the effect of orexin cell grafts into the lateral hypothalamus (LH) on narcoleptic-like sleep behavior. Rats received bilateral 490-ng injections of orexin-SAP* into the LH. 21 days post-lesion, the animals then received a graft consisting of dissociated cells from a 8-10 day old rat brain. The narcoleptic-like behavior was reduced in animals receiving the graft, indicating that restoration of some orexin levels may help resolve neurodegeneration.

Related Products: Orexin-B-SAP (Cat. #IT-20)