Author name: Kristen Hartman

Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy.

Cordier D, Gerber A, Kluba C, Bauman A, Hutter G, Mindt TL, Mariani L (2014) Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy. Cancer Biother Radiopharm 29(5):221-226. doi: 10.1089/cbr.2013.1588 Summary: The neurokinin-1 receptor (NK1r) has been found to be consistently over-expressed in gliomas, making it a potential target […]

Expression of different neurokinin-1 receptor (NK1R) isoforms in glioblastoma multiforme: potential implications for targeted therapy. Read More »

Cholinergic immunotoxin 192 IgG-saporin alters subicular theta-gamma activity and impairs spatial learning in rats.

Rastogi S, Unni S, Sharma S, Laxmi T, Kutty B (2014) Cholinergic immunotoxin 192 IgG-saporin alters subicular theta-gamma activity and impairs spatial learning in rats. Neurobiol Learn Mem 114:117-126. doi: 10.1016/j.nlm.2014.05.008 Summary: The authors investigated the role of the subiculum in spatial informational processing, specifically cholinergic modulation of subicular theta-gamma activity. Rats received 50-ng injections

Cholinergic immunotoxin 192 IgG-saporin alters subicular theta-gamma activity and impairs spatial learning in rats. Read More »

Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release.

Nunan R, Sivasathiaseelan H, Khan D, Zaben M, Gray W (2014) Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia 62:1313-1327. doi: 10.1002/glia.22682 Summary: Postnatal and adult learning and memory require hippocampal neurogenesis. Cognitive dysfunction is frequently accompanied by neuroinflammatory pathogenesis, but the pathways by which the immune

Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Read More »

[Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats].

Cao J, Wu T, Zhang L (2014) [Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 30:218-222. Summary: Pain threshold, 5-hydroxytryptamine (5-HT) expression, and c-Fos expression were measured in rats after

[Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. Read More »

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin.

Alonso M, Gregorio J, Davidson M, Gonzalez J, Engleman E (2014) Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin. Immunol Res 58:374-377. doi: 10.1007/s12026-014-8511-6 Objective: To investigate a strategy that avoids monocyte intermediates to deplete inflammatory dendritic cells (DCs). Mice with an abundance of inflammatory DCs as a consequence of lipopolysaccharide exposure

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin. Read More »

Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions.

Vetrivelan R, Saper C, Fuller P (2014) Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep 6:57-63. doi: 10.2147/NSS.S53132 Summary: Excessive daytime sleepiness is often treated with modafinil. Armodafinil, the R-isomer of modafinil, has been introduced for clinical use, but little is known about the cellular pathway targeted by these drugs. The authors

Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Read More »

Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress.

Flak J, Myers B, Solomon M, McKlveen J, Krause E, Herman J (2014) Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. Eur J Neurosci 39:1903-1911. doi: 10.1111/ejn.12587 Summary: Chronic stress can cause dysregulation of the paraventricular nucleus (PVN) of the hypothalamus, resulting in structural and function changes in the neurons involved. There

Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. Read More »

Role of lateral hypothalamus in two aspects of attention in associative learning.

Wheeler D, Wan S, Miller A, Angeli N, Adileh B, Hu W, Holland P (2014) Role of lateral hypothalamus in two aspects of attention in associative learning. Eur J Neurosci 40:2359-2377. doi: 10.1111/ejn.12592 Summary: The lateral hypothalamic (LH) region contains both orexin and melanin-concentrating hormone (MCH) neurons. These neurons are unique to the LH but

Role of lateral hypothalamus in two aspects of attention in associative learning. Read More »

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