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Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions.

Vetrivelan R, Saper C, Fuller P (2014) Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions. Nat Sci Sleep 6:57-63. doi: 10.2147/NSS.S53132

Summary: Excessive daytime sleepiness is often treated with modafinil. Armodafinil, the R-isomer of modafinil, has been introduced for clinical use, but little is known about the cellular pathway targeted by these drugs. The authors examined whether armodafinil inhibits the ventrolateral preoptic nucleus (VLPO). Rats received 200-ng injections of orexin-SAP into the VLPO, followed by administration of armodafinil. Lesioned animals displayed increased wakefulness similar to control animals, indicating that armodafinil and modafinil do not act along the VLPO neurons.

Related Products: Orexin-B-SAP (Cat. #IT-20)