Wang C, Pan C, Yong H, Wang F, Bo T, Zhao Y, Ma B, He W, Li M (2023) Emerging non-viral vectors for gene delivery. J Nanobiotechnology 21(1):272. doi: 10.1186/s12951-023-02044-5 PMID: 37592351 Summary: This review describes the fastest-growing and efficient non-viral gene delivery vectors that include liposomes and lipid nanoparticles (LNPs), highly branched poly(β-amino ester) […]
Emerging non-viral vectors for gene delivery Read More »
Liu X, Si W, Zhao Z, Liu N, Yang Q, Zhou R, Zhu R, Duan S, CHen Y, Yin L (2023) Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment. Sci China Chem doi: 10.1007/s11426-023-1684-5 Objective: Using M2-D, a blood brain penetrating pro-protein, conjugated to saporin to kill glioblastoma cells in mice. Summary: M2-D,
Liu X, Si W, Zhao Z, Liu N, Yang Q, Zhou R, Zhu R, Duan S, CHen Y, Yin L (2023) Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment. Sci China Chem doi: 10.1007/s11426-023-1684-5 Objective: Using M2-D, a blood brain penetrating pro-protein, conjugated to saporin to kill glioblastoma cells in mice. Summary: M2-D,
Miles AJ, Drew ED, Wallace BA (2023) DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy. Commun Biol 6(1):823. doi: 10.1038/s42003-023-05178-2 PMID: 37553525 Objective: To use DichroIDP software to analyze secondary structures of proteins containing disordered structures via circular dichroism spectroscopy. Summary: Globular proteins have specific shapes and mainly contain standard
Ploeg E (2023) Novel approaches towards cancer-directed immune checkpoint inhibition. Univ Groningen Thesis. doi: 10.33612/diss.737906343 Objective: To evaluate a novel bispecific antibody, bsAb CD73xEGFR, that inhibits the immunosuppressive enzyme CD73 on cancer cells in an EGFR-directed manner. Summary: The researchers constructed a bispecific antibody, bsAb CD73xEGFR, that binds to both CD73 and EGFR on cancer
Novel approaches towards cancer-directed immune checkpoint inhibition Read More »
Jorgensen MD (2023) Designing coiled-coil peptide materials for biomedical applications. Purdue University Thesis. Objective: Using saporin [PR-01] containing hydrogel to target and eliminate cancer cells. Summary: Hydrogels can bind molecular cargo and be used to shuttle cytotoxic drugs across the body. Using a pH-responsive hyaluronic acid nanogel containing saporin, cancer cells with overexpressed CD44 receptor
Designing coiled-coil peptide materials for biomedical applications Read More »
Jin X, Yang GY (2023) Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases. Prog Lipid Res 101241. doi: 10.1016/j.plipres.2023.101241 PMID: 37524133 Objective: The authors review the tumor-related biological functions of GSLs and recent progress in using GSLs and related enzymes to diagnose and treat tumor diseases. Summary: Glycosphingolipids (GSLs)
Zhang H, Zhu Y, Chen S, Deng K, Zheng M, Zeng Z, Wang Q, Cai H, Lu Z (2023) Autonomic nerve and its modulation approaches for heart failure. Brain & Heart 1(2):0913. doi: 10.36922/bh.0913 Objective: Authors review neural modulation approaches that can assist in the management of heart failure. Summary: The autonomic nervous system governs
Autonomic nerve and its modulation approaches for heart failure Read More »
Canarutto D, Omer Javed A, Pedrazzani G, Ferrari S, Naldini L (2023) Mobilization-based engraftment of haematopoietic stem cells: a new perspective for chemotherapy-free gene therapy and transplantation. Br Med Bull ldad017. doi: 10.1093/bmb/ldad017 PMID: 37460391 Objective: The authors review alternative chemotherapy-free approaches to niche voidance that could replace conventional regimens and alleviate the morbidity of
Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature Patrick A. Shramm, Denise Higgins, Douglas A. Lappi • Advanced Targeting Systems, Carlsbad, CA Abstract Introduction: NPY-SAP is a conjugate of Neuropeptide Y and the ribosome-inactivating protein (RIP) saporin. The idea behind the invention of NPY-SAP is to introduce it using the ligand’s
Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature Read More »