Author name: Kristen Hartman

The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression

Kfoury YS, Ji F, Jain E, Mazzola MC, Schiroli G, Papazian A, Mercier FE, Sykes DB, Kiem A, Randolph MA, Abdel-Wahab OI, Calvi LM, Sadreyev R, Scadden DT (2023) The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression. Blood Adv bloodadvances.2022008268. doi: 10.1182/bloodadvances.2022008268 PMID: 37450380 Objective: Evaluate mesenchymal cell molecular […]

The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression Read More »

Differential role of GABaergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping

Akmese C, Sevinc C, Halim S, Unal G (2023) Differential role of GABaergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping. Prog Neuropsychopharmacol Biol Psychiatry 125:110760. doi: 10.1016/j.pnpbp.2023.110760 PMID: 37031946 Objective: To investigate the role of the ventral pallidum (VP) in regulating the brain’s reward circuitry in appetitive behaviors

Differential role of GABaergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping Read More »

Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress

Sun Z, Huang J, Fishelson Z, Wang C, Zhang S (2023) Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress. Biomedicines 11(7):1971. doi: 10.3390/biomedicines11071971 PMID: 37509610 Objective: Review the development process of cell penetrating peptides and summarize the composition and classification of the penetrating peptide-based delivery systems, cellular uptake mechanisms, influencing factors, and biological

Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress Read More »

Custom Biotinylation Service Overview

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Also available in Chinese | French | German | Italian | Japanese | Korean | Portuguese | Spanish Leonardo Ancheta, Vice President and Director of Custom Conjugations at ATS, talks about important things to watch for to avoid compromising your next experiment. keywords: biotinylation service, custom, streptavidin-ZAP, streptavidinylated saporin, biotin, linker, target-binding affinity, stable, payload,

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Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery

Yang Q, Liu N, Zhao Z, Liu X, Yin L (2024) Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery. Nano Research 17:1760-1771. doi: 10.1007/s12274-023-5978-2 Objective: Improve protein delivery with the synthesis of epigallocatechin gallate/low-molecular-weight polyethylenimine/2-acetylphenylboric acid (EPP)-protein nano-capsules. Summary: A protein delivery strategy was created through the crosslinking of various markers on

Dynamically crosslinked nanocapsules for the efficient and serum-resistant cytosolic protein delivery Read More »

Cannabinoids: Emerging sleep modulator

Low ZXB, Lee XR, Soga T, Goh BH, Alex D, Kumari Y (2023) Cannabinoids: Emerging sleep modulator. Biomed Pharmacother 165:115102. doi: 10.1016/j.biopha.2023.115102 PMID: 37406510 Objective: To review the modulation of sleep by cannabinoids and the endocannabinoid system. Summary: This review article discusses the role of cannabinoids, including endocannabinoids like anandamide and phytocannabinoids like THC and

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A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors.

Targeting Topics /

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Shramm PA, Ancheta L, Higgins D, Lappi DA (2017) Society for Neuroscience, Washington, DC. Abstract Some of the most recent successes in the treatment of cancers have been from antibodies to cell surface proteins

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Read More »

A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles

Gandek TB, van der Koog L, Nagelkerke A (202329) A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles. Adv Healthc Mater e2300319 doi: 10.1002/adhm.202300319 PMID: 37384827 Objective: Using peptide-functionalized extracellular vesicles (EVs), filled with saporin, to increase cytotoxicity over normal biological EVs. Summary: Extracellular vesicles were used as

A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles Read More »

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

Watts NR, Eren E, Palmer I, Huang PL, Huang PL, Shoemaker RH, Lee-Huang S, Wingfield PT (2023) The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2. PLoS One 18(6):e0286370. doi: 10.1371/journal.pone.0286370 PMID: 37384752 Summary: Saporin is mentioned in the discussion of RIPs and their usage as antivirals. Related Products: Saporin (Cat. #PR-01) See Also: Arslan I

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