Author name: Kristen Hartman

The induction of long-term potentiation by medial septum activation under urethane anesthesia can alter gene expression in the hippocampus

Dobryakova YV, Gerasimov K, Spivak YS, Korotkova T, Koryagina A, Deryabina A, Markevich VA, Bolshakov AP (2023) The induction of long-term potentiation by medial septum activation under urethane anesthesia can alter gene expression in the hippocampus. Int J Mol Sci 24(16):12970. doi: 10.3390/ijms241612970 PMID: 37629149 Objective: To study changes in the expression of early genes […]

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Emerging non-viral vectors for gene delivery

Wang C, Pan C, Yong H, Wang F, Bo T, Zhao Y, Ma B, He W, Li M (2023) Emerging non-viral vectors for gene delivery. J Nanobiotechnology 21(1):272. doi: 10.1186/s12951-023-02044-5 PMID: 37592351 Summary: This review describes the fastest-growing and efficient non-viral gene delivery vectors that include liposomes and lipid nanoparticles (LNPs), highly branched poly(β-amino ester)

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Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment

Liu X, Si W, Zhao Z, Liu N, Yang Q, Zhou R, Zhu R, Duan S, Chen Y, Yin L (2023) Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment. Sci China Chem doi: 10.1007/s11426-023-1684-5 Objective: Using M2-D, a blood brain penetrating pro-protein, conjugated to saporin to kill glioblastoma cells in mice. Summary: M2-D,

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DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy

Miles AJ, Drew ED, Wallace BA (2023) DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy. Commun Biol 6(1):823. doi: 10.1038/s42003-023-05178-2 PMID: 37553525 Objective: To use DichroIDP software to analyze secondary structures of proteins containing disordered structures via circular dichroism spectroscopy. Summary: Globular proteins have specific shapes and mainly contain standard

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Designing coiled-coil peptide materials for biomedical applications

Jorgensen MD (2023) Designing coiled-coil peptide materials for biomedical applications. Purdue University Thesis. Objective: Using saporin [PR-01] containing hydrogel to target and eliminate cancer cells. Summary: Hydrogels can bind molecular cargo and be used to shuttle cytotoxic drugs across the body. Using a pH-responsive hyaluronic acid nanogel containing saporin, cancer cells with overexpressed CD44 receptor

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Novel approaches towards cancer-directed immune checkpoint inhibition

Ploeg E (2023) Novel approaches towards cancer-directed immune checkpoint inhibition. Univ Groningen Thesis. doi: 10.33612/diss.737906343 Objective: To evaluate a novel bispecific antibody, bsAb CD73xEGFR, that inhibits the immunosuppressive enzyme CD73 on cancer cells in an EGFR-directed manner. Summary: The researchers constructed a bispecific antibody, bsAb CD73xEGFR, that binds to both CD73 and EGFR on cancer

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Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases

Jin X, Yang GY (2023) Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases. Prog Lipid Res 101241. doi: 10.1016/j.plipres.2023.101241 PMID: 37524133 Objective: The authors review the tumor-related biological functions of GSLs and recent progress in using GSLs and related enzymes to diagnose and treat tumor diseases. Summary: Glycosphingolipids (GSLs)

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Mobilization-based engraftment of haematopoietic stem cells: a new perspective for chemotherapy-free gene therapy and transplantation

Canarutto D, Omer Javed A, Pedrazzani G, Ferrari S, Naldini L (2023) Mobilization-based engraftment of haematopoietic stem cells: a new perspective for chemotherapy-free gene therapy and transplantation. Br Med Bull ldad017. doi: 10.1093/bmb/ldad017 PMID: 37460391 Objective: The authors review alternative chemotherapy-free approaches to niche voidance that could replace conventional regimens and alleviate the morbidity of

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Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature

Targeting Topics /

Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature Patrick A. Shramm, Denise Higgins, Douglas A. Lappi • Advanced Targeting Systems, Carlsbad, CA Abstract Introduction: NPY-SAP is a conjugate of Neuropeptide Y and the ribosome-inactivating protein (RIP) saporin. The idea behind the invention of NPY-SAP is to introduce it using the ligand’s

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