Liu X, Si W, Zhao Z, Liu N, Yang Q, Zhou R, Zhu R, Duan S, Chen Y, Yin L (2023) Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment. Sci China Chem doi: 10.1007/s11426-023-1684-5
Objective: Using M2-D, a blood brain penetrating pro-protein, conjugated to saporin to kill glioblastoma cells in mice.
Summary: M2-D, a blood brain penetrating pro-protein, is conjugated to saporin allowing the cytotoxicity of saporin to reach through the brain in a L-type amino acid transport mediated delivery. M2D-Saporin demonstrated selective killing of glioblastoma cells in mice and didn’t exhibit general systemic toxicity.
Usage: Cy5-Saporin or Cy5-saporin-M2-D was i.v. injected to BALB/c mice at 0.5 mg Cy5-saporin/kg
Related Products: Saporin (Cat. #PR-01)