Author name: Kristen Hartman

Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells

Hayashi R, Ishikawa Y, Katori R, Sasamoto Y, Taniwaki Y, Takayanagi H, Tsujikawa M, Sekiguchi K, Quantock AJ, Nishida K (2017) Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells. Nat Protoc 12:683-696. doi: 10.1038/nprot.2017.007 PMID: 28253236 Usage: IHC 1:100 Related Products: NGFr (ME20.4, p75) […]

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Melanopsin photoresponse relies on the SEE-terminus

Targeting Topics /

Somasundaram et al. C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. PNAS (2017), pii: 201611893. PMID: 28223508 Chronotype (morningness-eveningness) in mammals likely has multiple causes. Phase angle of entrainment is defined as the relationship between the timing of the biological clock and the timing of an external time cue, and if the primary

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Lipid mapping of the rat brain for models of disease.

Martínez-Gardeazabal J, González de San Román E, Moreno-Rodríguez M, Llorente-Ovejero A, Manuel I, Rodríguez-Puertas R (2017) Lipid mapping of the rat brain for models of disease. Biochim Biophys Acta Biomembr 1859:1548-1557.. doi: 10.1016/j.bbamem.2017.02.011 Objective: To map the spatial distribution of different lipid species in the rat central nervous system (CNS) using IMS to find a

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Chronic lithium treatment in a rat model of basal forebrain cholinergic depletion: Effects on memory impairment and neurodegeneration.

Gelfo F, Cutuli D, Nobili A, De Bartolo P, D’Amelio M, Petrosini L, Caltagirone C (2017) Chronic lithium treatment in a rat model of basal forebrain cholinergic depletion: Effects on memory impairment and neurodegeneration. J Alzheimers Dis 56:1505-1518. doi: 10.3233/JAD-160892 PMID: 28222508 Objective: To evaluate the potential beneficial effects of a chronic lithium treatment in

Chronic lithium treatment in a rat model of basal forebrain cholinergic depletion: Effects on memory impairment and neurodegeneration. Read More »

Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APP

Joly S, Lamoureux S, Pernet V (2017) Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APP. Neurobiol Aging 53:181-191. doi: 10.1016/j.neurobiolaging.2017.02.004 PMID: 28262325 Objective: To determine amyloid beta role in the aging retina in Alzheimer’s Disease Summary: Retinal-specific processing of amyloid may confer protection against AD and

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Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation.

Lecrux C, Sandoe C, Neupane S, Kropf P, Toussay X, Tong X, Lacalle-Aurioles M, Shmuel A, Hamel E (2017) Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. J Neurosci 37:1518-1531. doi: 10.1523/JNEUROSCI.1784-16.2016 Summary: The authors assessed the effects of varying ACh tone on whisker-evoked NVC responses in rat barrel cortex.

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Neurovascular Coupling and Brain Imaging

Targeting Topics /

Lecrux et al. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. Journal of Neuroscience (2017), 1784-16. PMID: 28069927 Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to “neurovascular coupling” (NVC). It is unknown whether

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New Antibody Publications

Targeting Topics /

Jiao et al. Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves. EBioMedicine (2016) 10:282-90. PMID: 27394642 Individuals with bicuspid aortic valves (BAV) are at a higher risk of developing thoracic aortic aneurysms (TAA) than patients with trileaflet aortic valves (TAV). Aneurysms associated with BAV most commonly

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Fab-pHAST: The newest targeting tool

News Tools /

Contributed by Patrick Shramm, Product Manager for Fab-pHast We are pleased to announce a new set of tools to rapidly screen antibodies, Fab-pHast conjugates. The ATS pHAST product line provides the FASTEST results in quantitative testing of your antibody’s specific-binding and internalization. Fab-pHast contains a pH-dependent fluorescent reporter that increases intensity in acidic surroundings, such

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Cover Article: The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease.

News Article /

Contributed by S C Kelly, P T Nelson, S E Counts Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that most commonly affects individuals over the age of 65. While of unknown etiology, AD is characterized by a steady decline in cognitive functions including memory, attention, executive functions, and language. There is currently no disease-modifying therapy

Cover Article: The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease. Read More »

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