Role of A5 noradrenergic neurons in the chemoreflex control of respiratory and sympathetic activities in unanesthetized conditions. Camilia L Taxini, Thiago S Moreira, Ana C Takakura, Daniel B Zoccal. Neuroscience 354:146-157, 2017. PMID: 28461215 The authors utilize Anti-DBH-SAP (Cat. #IT-03) to investigate the involvement of the A5 noradrenergic neurons to the basal and chemoreflex control of the sympathetic […]
Targeting Cholinergic Neurons with 192-IgG-SAP Lee et al. examined the effects of chronic stress on changes in spatial learning and underlying molecular signaling induced by cholinergic depletion. Previous studies revealed that loss of cholinergic input to the hippocampus reduces the expression of glucocorticoid receptors (GRs) and activates nuclear factor-kappa B (NF-κB) signaling through interactions with
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Yao P, Ding Y, Han Z, Mu Y, Hong T, Zhu Y, Li H (2017) Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors. Mol Pain 13:744806917708127. doi: 10.1177/1744806917708127 PMID: 28554249 Objective: To determine the functions and targeted suppression of asparaginyl endopeptidase (AEP) in a mouse model of breast cancer-induced
Taylor BK, Westlund KN (2017) The noradrenergic locus coeruleus as a chronic pain generator. J Neurosci Res 95(6):1336-1346. doi: 10.1002/jnr.23956 PMID: 27685982 Objective: To evaluate whether noradrenergic neurons of the locus coeruleus contribute to the generation and maintenance of chronic neuropathic pain rather than serving solely a pain inhibitory role. Summary: This review synthesizes evidence
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Lowe D, Bivens C, Mobley A, Herrera C, McCormick A, Wichner T, Sabnani M, Wood L, Weidanz J (2017) TCR-like antibody drug conjugates mediate killing of tumor cells with low peptide/HLA targets. MAbs 9:603-614. doi: 10.1080/19420862.2017.1302630 Objective: To analyze the killing potential of TCR-like ADCs. Summary: Data comprise proof-of-principle results that TCR-like ADCs mediate potent
Lee S, Cho W, Lee Y, Han J (2018) Impact of chronic stress on the spatial learning and GR-PKAc-NF-κB signaling in the hippocampus and cortex in rats following cholinergic depletion. Mol Neurobiol 55:3976-3989. doi: 10.1007/s12035-017-0620-5 Objective: Examine the effects of chronic stress on cognitive status and GR-PKAc-NF-κB signaling in rats with a loss of cholinergic
In a study produced by Ferrini et al. indicates that morphine-induced hyperalgesia, as neuropathic pain, is a pathological alteration of pain sensitivity whose expression is gated by spinal microglia. Targeting at any level, this microglia-to-neuron cascade is a valuable strategy to improve the use of morphine in chronic pain. Ferrini F, Trang T, Mattioli TA,
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Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F, King T (2017) Mediation of movement-induced breakthrough cancer pain by IB4-binding nociceptors in rats. J Neurosci 37:5111-5122.. doi: 10.1523/JNEUROSCI.1212-16.2017 Objective: To define a novel preclinical measure of movement-induced breakthrough pain (BTP) that is observed in the presence
Wu W, Wu XL, Ji YQ, Gao Z (2017) Differentiation of nestin‑negative human hair follicle outer root sheath cells into neurons in vitro. Mol Med Rep 16(1):95-100. doi: 10.3892/mmr.2017.6585 PMID: 28534946 Objective: To isolate nestin-negative outer root sheath cells (ORSCs) from adult healthy volunteers and investigate the neuronal differentiation of these cells. Summary: The present
ZAP Antibody Internalization Kits allow a large number of antibodies to be screened quickly and cost-effectively for specificity, functional binding, internalization, and EC50 determination. The wide selection of these secondary conjugates provide ideal tools for screening potential antibodies . They are constructed using either species-specific polyclonal anti-IgG antibodies, or streptavidin (alternate kit for use with biotinylated
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