Taylor BK, Westlund KN (2017) The noradrenergic locus coeruleus as a chronic pain generator. J Neurosci Res 95(6):1336-1346. doi: 10.1002/jnr.23956 PMID: 27685982
Objective: To evaluate whether noradrenergic neurons of the locus coeruleus contribute to the generation and maintenance of chronic neuropathic pain rather than serving solely a pain inhibitory role.
Summary: This review synthesizes evidence showing that noradrenergic signaling from the locus coeruleus can facilitate neuropathic pain following nerve injury, challenging the traditional view of the LC as purely analgesic. Collectively, lesion, pharmacological, and circuit-level studies support a time dependent shift from pain inhibition to pain facilitation mediated by noradrenergic pathways.
Usage: This review summarizes multiple studies that utilized Anti-DBH-SAP (IT-03) to selectively ablate central noradrenergic neurons via intracerebroventricular or region-specific injections, demonstrating reduced mechanical and cold hypersensitivity in rodent models of neuropathic pain.
Related Products: Anti-DBH-SAP (Cat. #IT-03)