Author name: Kristen Hartman

Hosts and heterologous expression strategies of recombinant toxins for therapeutic purposes

di Leandro L, Colasante M, Pitari G, Ippoliti R (2023) Hosts and heterologous expression strategies of recombinant toxins for therapeutic purposes. Toxins (Basel) 15(12):699. doi: 10.3390/toxins15120699 PMID: 38133203 Objective: Review the recombinant expression of toxins from bacterial, plant, or animal species used as components of immunotoxins. Summary: Commercial production of recombinant proteins for therapeutic purposes […]

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Chemical design of a supramolecular protein nanoplatform for therapeutic applications

Heck AJ (2023) Chemical design of a supramolecular protein nanoplatform for therapeutic applications. Univ Johannes Gutenberg Thesis. Objective: Investigate the potential of using multivalent proteins as an integrative nanoplatform to target protein hallmarks in various diseases by forming supramolecular protein conjugates (SPC). Summary: The author employs an integrative and adaptable protein-based nanoplatform to combine bioactive

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Chemical design of a supramolecular protein nanoplatform for therapeutic applications

Heck AJ (2023) Chemical design of a supramolecular protein nanoplatform for therapeutic applications. Univ Johannes Gutenberg Thesis. Objective: Investigate the potential of using multivalent proteins as an integrative nanoplatform to target protein hallmarks in various diseases by forming supramolecular protein conjugates (SPC). Summary: The author employs an integrative and adaptable protein-based nanoplatform to combine bioactive

Chemical design of a supramolecular protein nanoplatform for therapeutic applications Read More »

Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens

Loftén A, Adermark L, Ericson M, Söderpalm B (2023) Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens. Addict Biol 28(12):e13349. doi: 10.1111/adb.13349 PMID: 38017639 Objective: The aim of this study was to explore the role of glycine receptors (GlyRs) on cholinergic interneurons (CIN) in sustaining extracellular dopamine

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Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system

Takanami K, Kuroiwa M, Ishikawa R, Imai Y, Oishi A, Hashino M, Shimoda Y, Sakamoto H, Koide T (2023) Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system. Front Mol Neurosci 16:1280024. doi: 10.3389/fnmol.2023.1280024 PMID: 38098939 Objective: To investigate the role of gastrin-releasing peptide (GRP) and GRP receptor (GRPR)

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Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

Singh RR, Mondal I, Janjua T, Popat A, Kulshreshtha R (2023) Engineered smart materials for RNA based molecular therapy to treat Glioblastoma. Bioact Mater 33:396-426. doi: 10.1016/j.bioactmat.2023.11.007 PMID: 38059120 Objective: A review of non-coding RNA therapy and its targeted delivery of nucleic acids to treat Glioblastoma, emphasizing smart nano-materials. Summary: Nano-carriers of ncRNA can offer

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The specificity landscape of bacterial ribonuclease P

Chamberlain AR, Huynh L, Huang W, Taylor DJ, Harris ME (2023) The specificity landscape of bacterial ribonuclease P. J Biol Chem 300(1):105498. doi: 10.1016/j.jbc.2023.105498 PMID: 38013087 Objective: Review of the specificity of ribonucleoprotein RNase P in binding different types of RNA. Summary: Ribonucelase P is involved in the RNA metabolism pathways. By studying the rate

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Neuroscience

Targeting Topics /

The Advanced Targeting Systems targeting technology provides neuroscientists with the tools to identify, visualize, and or eliminate specific cell types. Some examples of scientific studies using ATS products include Learning and Memory, Circadian Rhythm, Sleeping and Wakefulness, Parkinson’s Disease, Alzheimer’s Disease, Addiction, Multiple Sclerosis, Pain Mechanisms, Eating and Diet. Learning and Memory Galanin-SAP [IT-34] PACAP-SAP

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CLEC2A is a novel AML-restricted immunotherapeutic target enriched in KMT2A-rearranged acute myeloid leukemia

Kirkey DC, Robinson L, Janssens D, Hines MG, Hylkema T, Manselle MK, Ries RE, Peplinski JH, Wallace LK, Otto D, Tarlock K, Henikoff S, Li W, Meshinchi S (2023) CLEC2A is a novel AML-restricted immunotherapeutic target enriched in KMT2A-rearranged acute myeloid leukemia. Blood 142(1):290. doi: 10.1182/blood-2023-188439 Objective: Targeting CLEC2A, a novel immunotherapeutic target, in the

CLEC2A is a novel AML-restricted immunotherapeutic target enriched in KMT2A-rearranged acute myeloid leukemia Read More »

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