Author name: Kristen Hartman

Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells

Gong S, Qiu J, Thayumanavan S (2024) Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells. J Am Chem Soc 146(1):33-38. doi: 10.1021/jacs.3c09334 PMID: 38147631 Objective: To describe a simple self-assembly strategy for generating artificial immune complexes. Summary: The built-in recognition domains in the antibody, viz. the Fab and Fc domains, […]

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Heterophyllin: A new adenia toxic lectin with peculiar biological properties

Bortolotti M, Biscotti F, Zanello A, Polito L, Bolognesi A (2024) Heterophyllin: A new adenia toxic lectin with peculiar biological properties. Toxins 16(1):1. doi: 10.3390/toxins16010001 PMID: 38276525 Objective: Describe the novel type II Ribosome Inactivating Protein, Heterophyllin. Summary: Heterophyllin, a novel toxic lectin from Adenia heterophylla shows enzymatic and lectin properties of type 2 RIPs.

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Intracellular protein delivery: Approaches, challenges, and clinical applications

Chan A, Tsourkas A (2024) Intracellular protein delivery: Approaches, challenges, and clinical applications. BME Frontiers 5:0035. doi: 10.34133/bmef.0035 PMID: 38282957 Objective: To review progress made towards achieving cytosolic delivery of recombinant proteins and possible strategies to enable proteins to cross cell membranes. Summary: Drug delivery researchers have worked to deliver saporin into tumor cells in

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Immunomodulatory impact of memory T lymphocyties in periodontitis

de Paula FS (2023) Immunomodulatory impact of memory T lymphocyties in periodontitis. Univ Minnesota Thesis. Objective: This thesis paper sought to determine whether local reactivation of oral tissue resident memory cells (TRM) of a defined antigen specificity could exacerbate ligature-induced periodontal (LIP), a model for periodontal disease in mice. Summary: Reactivation of oral TRM aggravated

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Hosts and heterologous expression strategies of recombinant toxins for therapeutic purposes

di Leandro L, Colasante M, Pitari G, Ippoliti R (2023) Hosts and heterologous expression strategies of recombinant toxins for therapeutic purposes. Toxins (Basel) 15(12):699. doi: 10.3390/toxins15120699 PMID: 38133203 Objective: Review the recombinant expression of toxins from bacterial, plant, or animal species used as components of immunotoxins. Summary: Commercial production of recombinant proteins for therapeutic purposes

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Chemical design of a supramolecular protein nanoplatform for therapeutic applications

Heck AJ (2023) Chemical design of a supramolecular protein nanoplatform for therapeutic applications. Univ Johannes Gutenberg Thesis. Objective: Investigate the potential of using multivalent proteins as an integrative nanoplatform to target protein hallmarks in various diseases by forming supramolecular protein conjugates (SPC). Summary: The author employs an integrative and adaptable protein-based nanoplatform to combine bioactive

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Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens

Loftén A, Adermark L, Ericson M, Söderpalm B (2023) Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens. Addict Biol 28(12):e13349. doi: 10.1111/adb.13349 PMID: 38017639 Objective: The aim of this study was to explore the role of glycine receptors (GlyRs) on cholinergic interneurons (CIN) in sustaining extracellular dopamine

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Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system

Takanami K, Kuroiwa M, Ishikawa R, Imai Y, Oishi A, Hashino M, Shimoda Y, Sakamoto H, Koide T (2023) Function of gastrin-releasing peptide receptors in ocular itch transmission in the mouse trigeminal sensory system. Front Mol Neurosci 16:1280024. doi: 10.3389/fnmol.2023.1280024 PMID: 38098939 Objective: To investigate the role of gastrin-releasing peptide (GRP) and GRP receptor (GRPR)

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Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

Singh RR, Mondal I, Janjua T, Popat A, Kulshreshtha R (2023) Engineered smart materials for RNA based molecular therapy to treat Glioblastoma. Bioact Mater 33:396-426. doi: 10.1016/j.bioactmat.2023.11.007 PMID: 38059120 Objective: A review of non-coding RNA therapy and its targeted delivery of nucleic acids to treat Glioblastoma, emphasizing smart nano-materials. Summary: Nano-carriers of ncRNA can offer

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