Kristen Hartman – Page 101 – Advanced Targeting Systems

Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats

Andrews JL, Newell KA, Matosin N, Huang XF, Fernandez F (2018) Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats. Neuronal Signal 2(3):NS20180059. doi: 10.1042/NS20180059 PMID: 32714588 Objective: To investigate the effects of perinatal phencyclidine (PCP) administration on levels of expression of Lingo-1 signaling […]

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Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity.

Kristen Hartman

Virga DM, Capps J, Vohra BPS (2018) Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity. Neurochem Res 43(12):2288-2303. doi: 10.1007/s11064-018-2649-x PMID: 30259276 Objective: To investigate the mechanism by which enteric nervous system degeneration occurs in Parkinson’s Disease. Summary: Therapies targeting both axonal and somal protection can be important

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Cytoplasmic Delivery of Aptamers

Targeting Topics / Kristen Hartman

Screening Aptamers as Targeting Agents to deliver Payloads. Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for

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Cross-talk between distinct receptors shapes itch behavior in the spinal cord.

Kristen Hartman

Meng QT, Liu XY, Liu XT, Barry DM, Jin H, Yang Q, Sun Y, Wan L, Jin JH, Munanairi A, Kim R, Yin J, Tao A, Chen ZF (2018) Cross-talk between distinct receptors shapes itch behavior in the spinal cord. Neuron doi: 10.2139/ssrn.3249822 Summary: Consistently, Nppb-SAP ablated spinal Npr1 and Npr3 neurons and impaired histamine-,

Cross-talk between distinct receptors shapes itch behavior in the spinal cord. Read More »

Neuropharmacology of attention

Kristen Hartman

Burk JA, Blumenthal SA, Maness EB (2018) Neuropharmacology of attention. Eur J Pharmacol 835:162-168. doi: 10.1016/j.ejphar.2018.08.008 Objective: This review focuses on the knowledge gained about neurotransmitter systems with respect to attentional processing, with emphasis on the functions mediated within the medial prefrontal cortex. Summary: Future research needs to facilitate a better comprehension of the neural

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Tools to study Programmed Cell Death

Targeting Topics / Kristen Hartman

Antibodies you can rely on. The authors investigated the interactions of pro-survival and pro-apoptotic receptors in Programmed Cell Death (PCD) using the sympathetic nervous system as a model. They demonstrate that Ret, a receptor tyrosine kinase required for the survival of many neuronal populations, is restricted to a subset of degenerating neurons that rapidly undergo

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Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer

Kristen Hartman

Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B (2018) Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight 3(17):e121497. doi: 10.1172/jci.insight.121497 PMID: 30185663 Objective: To investigate the suitability of

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Molecular diversity of intrinsically photosensitive ganglion cells

Kristen Hartman

Berg D, Kartheiser K, Leyrer M, Saali A, Berson D (2018) Molecular diversity of intrinsically photosensitive ganglion cells. bioRxiv 381004. doi: 10.1101/381004 Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

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Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line

Kristen Hartman

Yang WH, Cheng CY, Chen MF, Wang TC (2018) Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line. 38(9):5183-5192. doi: 10.21873/anticanres.12841 PMID: 30194166 Objective: This study is focused on the possible role of p75NTR in glioma tumor initiation. Summary: Cells with p75NTR overexpression demonstrated certain unique characteristics of tumor-initiating cells, such

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Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation.

Kristen Hartman

Lénárd L, László K, Kertes E, Ollmann T, Péczely L, Kovács A, Kállai V, Zagorácz O, Gálosi R, Karádi Z (2018) Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation. Neurosci Biobehav Rev 85:1-20. doi: 10.1016/j.neubiorev.2017.09.003 Summary: A specific neurotoxin, SSP-SAP can cause selective ablation of NK1 receptor expressing

Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation. Read More »

Author name: Kristen Hartman