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Cross-talk between distinct receptors shapes itch behavior in the spinal cord.

Meng QT, Liu XY, Liu XT, Barry DM, Jin H, Yang Q, Sun Y, Wan L, Jin JH, Munanairi A, Kim R, Yin J, Tao A, Chen ZF (2018) Cross-talk between distinct receptors shapes itch behavior in the spinal cord. Neuron . doi: 10.2139/ssrn.3249822

Summary: Consistently, Nppb-SAP ablated spinal Npr1 and Npr3 neurons and impaired histamine-, but not CQ-evoked, itch. Thus, the findings identify the role of BNP-NPRC signaling in modulation of histamine-evoked itch via NPRC-NMBR cross-talk independent of GRP-GRPR signaling. Our studies reveal distinct modes of action for bombesin-related peptides and NP in itch transmission.

Related Products: Nppb-SAP (Cat. #IT-69)