Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Kayla L. Nguyen1, Sydney R. Lamerand1, Ronit P. Deshpande1, Bradley K. Taylor1,2 1Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA2Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA […]
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Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris Water Maze and Object-Place Paired Association tasks by Argyle V. Bumanglag1, Leah M. Truckenbrod1, Eugene Chun2, Abbi R. Hernandez1, Quinten P. Federico1, Andrew P. Maurer1, Robert S. Sloviter3,4, Sara N. Burke1 1Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL,
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ATS and Cytologistics move to Carlsbad Read More »
Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology
Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts Read More »
by Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, Gordon W. Arbuthnott.Brain Mechanism for Behavior Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan Cholinergic interneurons (ChIs) are sparsely distributed within the striatum, a nucleus that plays important roles in voluntary motor control, associated learning, procedural memory, execution of movement, action selection, and planning.[1] ChIs
Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons Read More »
On December 5, 2017, Dr. Roger Guillemin was honored by Université de Montréal by the naming of its assembly hall after him. The honorary plaque will be installed at the entrance to the University Assembly hall, now re-named to mark the 40th anniversary of the French-born physician’s Nobel Prize for medicine. Salle Roger-Guillemin Born on
Roger Guillemin honored by Université de Montréal Read More »
Contributed by S C Kelly, P T Nelson, S E Counts Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that most commonly affects individuals over the age of 65. While of unknown etiology, AD is characterized by a steady decline in cognitive functions including memory, attention, executive functions, and language. There is currently no disease-modifying therapy
As we start a new year, we at Advanced Targeting Systems are more dedicated than ever to providing our customers with the innovative, cutting-edge tools that will accelerate and optimize research. Scientists around the world have published exciting new data to advance our knowledge of how specific cell types affect behavior and disease. With each new discovery, possibilities
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By Jigna Rajesh Kumar, [a, b, c, d] Ramamoorthy Rajkumar, [a, b, c] Liying Corinne Lee, [a, b, c] Gavin S. Dawe [a, b, c, d][a] Dept Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 117600, Singapore [b] Neurobiology and Ageing Programme, Life Sciences Institute, National University of
By Rahul Palchaudhuri, Ph.D., Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA Hematopoietic stem cell transplantation (HSCT) has been clinically used for 58 years and offers life-saving therapies for a variety of malignant and non-malignant blood disorders. Currently 50,000 transplants are performed globally per year with 90% of these for the