Tag Archives: 14q1

Targeting Trends Newsletter 14q1

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Tribute to Gangsta: A much-loved cat bids us adieu (page 2-7) Spring Brain Conference 25th Anniversary (page 2) Research Tools to Investigate Itch (page 7) […]

Targeting Tools: Investigating the Itch Pathway

Bombesin-SAP (Cat. #IT-40) Bombesin is a 14-amino-acid peptide found in frog-skin. The human equivalent, gastrin releasing peptide (GRP) has been detected in itch pathways and plays a role in eating behaviors. GRP regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. […]

Targeting Talk: Time Course

How long does it take to see the cell death occurring from the use of targeted toxins using saporin? Is there a time course of hours or days? The figure below illustrates the time course of cell death very effectively. Internalization and cytotoxicity of SP-SAP in primary cultures of neonatal spinal cord neurons (11). Confocal […]

Targeting Topics 14q1

BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease. Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. Proc Natl Acad Sci U S A 110(48):19567-19572, 2013. During development bone morphogenetic protein 9 (BMP9) induces the cholinergic phenotype in the basal forebrain. The authors investigated […]

Cover Article: FDA Gives Green Light to Human Clinical Trials for Cancer Pain

Contributed by Douglas A. Lappi, Ph.D., President/Chief Scientific Officer, Advanced Targeting Systems, San Diego, CA Substance P-Saporin (SP-SAP), ATS’s patented conjugate being developed for cancer pain therapy, has attracted a considerable amount of attention recently. Back-to-back publications, a press release and editorial were featured in the November issue of the journal Anesthesiology. The first article, […]