12q4

Targeting Trends Newsletter 12q4

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Spring Brain Conference, March 20-23, 2013 (page 2) SfN 2012 Poster Schedule (page 5) Teaser Winners (page 5) mu p75-SAP (page 7) Complete and Submit …

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Targeting Tools: mu p75-SAP

The cover article this quarter demonstrates usage of mu p75-SAP (Cat. #IT-16) to study delirium. To create this toxin, we affinity-purified the rabbit polyclonal to the low affinity neurotrophin receptor, p75, (Cat. #AB-N01AP) with the immunogen bound to a solid support, and then conjugated the affinity-purified antibody to saporin (Cat. #PR-01). As can be seen …

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Targeting Topics 12q4

Control of sleep and wakefulness. Brown RE, Basheer R, McKenna JT, Strecker RE, McCarley RW. Physiol Rev 92(3):1087-1187, 2012. This review summarizes mechanisms in the brain that control sleep and wakefulness. Areas discussed include wakefulness promoting systems, non-REM sleep and REM sleep definitions, the function of each kind of sleep, and dysfunction that occurs as …

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Cover Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation

Contributed by Dr. Colm Cunningham, Trinity College, Institute of Neuroscience & School of Biochemistry and Immunology, Dublin, Ireland It is well established that peripheral inflammation can signal the intact CNS to bring about adaptive changes in behavior during the sickness response. However, during aging and dementia, the brain is particularly susceptible to the deleterious effects …

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