12q4

Targeting Trends 2012 Newsletter

Read the 2012 Newsletters and recent scientific references 2012, issue 1:  Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry / by M St. Peters, M Sarter / featuring 192-IgG-SAP (Cat. #IT-01), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Anti-NGFr blocking antibody, Staining with FITC-labeled Anti-Saporin Targeting Tools: Antibody to Metabotropic Glutamate …

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Targeting Tools: mu p75-SAP

The cover article this quarter demonstrates usage of mu p75-SAP (Cat. #IT-16) to study delirium. To create this toxin, we affinity-purified the rabbit polyclonal to the low affinity neurotrophin receptor, p75, (Cat. #AB-N01AP) with the immunogen bound to a solid support, and then conjugated the affinity-purified antibody to saporin (Cat. #PR-01). As can be seen …

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Cover Article: Partial basal forebrain cholinergic depletion leaves working memory susceptible to the effects of systemic inflammation

Contributed by Dr. Colm Cunningham, Trinity College, Institute of Neuroscience & School of Biochemistry and Immunology, Dublin, Ireland It is well established that peripheral inflammation can signal the intact CNS to bring about adaptive changes in behavior during the sickness response. However, during aging and dementia, the brain is particularly susceptible to the deleterious effects …

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