12q1

Targeting Trends 2012 Newsletter

Read the 2012 Newsletters 2012, issue 1:  Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry / by M St. Peters, M Sarter / featuring 192-IgG-SAP (Cat. #IT-01), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Anti-NGFr blocking antibody, Staining with FITC-labeled Anti-Saporin Targeting Tools: Antibody to Metabotropic Glutamate Receptor 2, Tag-Targeted Toxins …

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Targeting Tools: Anti-mGluR2

There are eight known metabotropic glutamate receptors (mGluR) playing diverse roles in brain function and pathology. They are 7-transmembrane domain receptors involved in learning, memory, anxiety, synaptic plasticity, and pain perception. The ligand for these receptors is glutamate, which functions as an excitatory neurotransmitter. mGluR2 is involved in the inhibition of the cAMP cascade. Potentiation …

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Targeting Tools: Tag-Targeted Toxins

Tag-targeted toxins are new conjugates in the Targeted Toxins family. Antibodies specific for tags on expressed proteins are bound to the ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis). The conjugate binds to your tag that is expressed on the cell surface and then internalizes by antibody-mediated endocytosis. Saporin breaks away from …

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Targeting Topics 12q1

Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. Abbott SB, Stornetta RL, Coates MB, Guyenet PG. J Neurosci 31(45):16410-16422, 2011. Neurons in the retrotrapezoid nucleus (RTN) are involved in the CO2-dependent control of breathing in conscious and anesthetized rats. In this work the authors specifically examined Phox2b-expressing glutaminergic …

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Cover Article: Motivation’s modulation of attention through the mesolimbic-corticopetal cholinergic circuitry

Contributed by Megan St. Peters and Martin Sarter Departments of Psychology at Ferrum College, Ferrum, VA and University of Michigan, Ann Arbor, MI Increasing attentional “effort” as a result of challenging circumstances, and as a function to maintain or recover attentional performance, is pervasive in our daily lives.[1] Attentional effort is more than a function …

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