11q1

Targeting Trends 2011 Newsletter

Read the 2011 Newsletters 2011, issue 1: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue / by Goehler LE, Gaykema RPA / featuring Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18) SFN Poster of the Year Targeting Talk: Time Course for Toxins, Custom Mouse IgM Conjugate and Controls, Destroy Hippocampal Neurons …

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Targeting Tools: Anti-DBH-SAP

Anti-dopamine beta-hydroxylase-saporin (anti-DBH-SAP, Cat. #IT-03) is a highly specific noradrenergic lesioning agent. It specifically targets rat cells that express dopamine beta-hydroxylase and is also reported to react with mouse protein.1 This vesicular enzyme is exposed to the exterior milieu upon release of noradrenaline and thus allows these cells to be targeted with saporin. The specificity …

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Targeting Topics 11q1

The cell surface structure of Tumor Endothelial Marker 8 (TEM8) is regulated by the actin cytoskeleton Yang MY, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad MK, Frankel AE, St Croix B Biochim Biophys Acta 1813(1):39-49, 2011. Tumor endothelial marker 8 (TEM8) is a cell surface protein that is up-regulated on tumor blood vessels. …

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Cover Article: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue

Contributed by Lisa E. Goehler and Ronald P.A. Gaykema Center for the Study of Complementary and Alternative Therapies, University of Virginia School of Nursing, Charlottesville, VA 22908 Fatigue, experienced as reduced motivation and motor activity, is common in acute and chronic disease, including heart disease, cancer and cancer chemotherapy. Fatigue is part of a constellation …

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