11q1

Targeting Trends Newsletter 11q1

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights SFN Poster Winners (page 2) Teaser Winners (page 2) Anti-M-ZAP; IgM Controls; GAT1-SAP (page 5) Anti-DBH-SAP (page 7) Complete and Submit the Targeting Teaser online! …

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Targeting Tools: Anti-DBH-SAP

Anti-dopamine beta-hydroxylase-saporin (anti-DBH-SAP, Cat. #IT-03) is a highly specific noradrenergic lesioning agent. It specifically targets rat cells that express dopamine beta-hydroxylase and is also reported to react with mouse protein.1 This vesicular enzyme is exposed to the exterior milieu upon release of noradrenaline and thus allows these cells to be targeted with saporin. The specificity …

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Targeting Talk: Product Questions

I am interested in your product GAT1-SAP (Cat. #IT-32). Before ordering, I would like to know how long it takes until the toxin produces a lesion; Is seven days enough? The usual time-course for saporin toxins is that behavioral effects start appearing at four days and usually plateau at seven days. However, keep in mind …

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Targeting Topics 11q1

The cell surface structure of Tumor Endothelial Marker 8 (TEM8) is regulated by the actin cytoskeleton Yang MY, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad MK, Frankel AE, St Croix B Biochim Biophys Acta 1813(1):39-49, 2011. Tumor endothelial marker 8 (TEM8) is a cell surface protein that is up-regulated on tumor blood vessels. …

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Cover Article: Targeted Lesion of Caudal Brainstem Catecholamine Neurons Reveals Their Role in Symptoms of Fatigue

Contributed by Lisa E. Goehler and Ronald P.A. Gaykema Center for the Study of Complementary and Alternative Therapies, University of Virginia School of Nursing, Charlottesville, VA 22908 Fatigue, experienced as reduced motivation and motor activity, is common in acute and chronic disease, including heart disease, cancer and cancer chemotherapy. Fatigue is part of a constellation …

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