10q3

Targeting Trends Newsletter 10q3

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Basigin-2 research (page 2) Teaser Winners (page 2) Fab-ZAP protocol and toxicity (page 5) Targeting NGFr+ neurons(page 7) Complete and Submit the Targeting Teaser online! …

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Targeting Tools: CTB-SAP

CTB-SAP (Cat. #IT-14) is a conjugate between the cell-binding component of cholera toxin (the B chain) and saporin. CTB binds to GM1 (monosialotetrahexosylganglioside), which is present on the surface of different neurons. It has been suggested to be involved in many problems (besides the most famous in the gut: cholera) of neuronal systems: Parkinson’s, motor …

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Targeting Topics 10q3

Hindbrain Catecholamine Neurons Modulate the Growth Hormone But Not the Feeding Response to Ghrelin Emanuel AJ, Ritter S Endocrinology 151(7):3237-3246, 2010. In this work the authors investigated the role of hindbrain catecholamine neurons in the response to a gastrointestinal peptide, ghrelin. Rats received 42-ng injections of anti-DBH-SAP (Cat. #IT-03) into the paraventricular nucleus of the …

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Targeting Article: Poster at American Association for Cancer Research Meeting

At this year’s AACR meeting, Leonardo Ancheta, scientist and Product Manager from ATS, presented a poster on our new monoclonal antibody to Basigin-2 (Cat. #AB-42). The poster describes our work with the antibody and the immunotoxin made from it (Cat. #IT-54). Basigin-2 (EMMPRIN, CD147) is widely expressed on the surface of numerous tumor types and …

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Cover Article: Role of Cell Fate Determinants in a Model of Spinal Cord Neurotoxic Lesion Induced by Cholera Toxin B-Saporin

Contributed by Rosario Gulino, Vincenzo Perciavalle and Massimo Gulisan Dept of Physiological Sciences, Univ of Catania, Viale Andrea Doria, 6-I95125 Catania ITALY A promising approach for central nervous system (CNS) repair consists in the activation of endogenous neural precursor cells (NPCs), but this process is less efficient in the spinal cord (SC) following a spinal …

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