08q4

Targeting Trends 2008 Newsletter

2008, issue 1: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP / by Pang KCH, Jiao X, Servatius RJ / featuring GAT1-SAP (Cat. #IT-32) SFN Poster of the Year Targeting Talk: Secondary Conjugates & Reducing Agents Targeting Tools: New Products Stimulate Instead of Eliminate (SP-CTA [Substance …

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Targeting Tools: Anti-Saporin

Saporin is a plant enzyme with N-glycosidase activity that depurinates a specific nucleotide in the ribosomal RNA 28S, thus irreversibly blocking protein synthesis. Affinity-purified Anti-Saporin rabbit polyclonal (Cat. #AB-41AP) is the most recent addition to our line of Saporin antibodies. These antibodies can be used as controls with our Saporin-conjugate immunotoxins, for immunoblotting, and in …

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Targeting Talk: Saporin Clearance

I am planning an experiment to investigate the effects of ablation of spinal NK-1r-expressing cells (using intrathecal injection of SSP-SAP Cat#IT-11). In the first part of the experiment I want to destroy the NK-1r-expressing cells before surgical modification. I am unsure how long after injection of SSP-SAP I should carry out the surgery. I was …

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Targeting Topics 08q4

Tomoregulin internalization confers selective cytotoxicity of immunotoxins on prostate cancer cells. Zhao XY, Liu HL, Liu B, Willuda J, Siemeister G, Mahmoudi M, Dinter H Transl Oncol 1:102-109, 2008. Tomoregulin is a type 1 transmembrane protein with a short cytoplasmic tail, and is found in the brain and prostate. After confirming cell surface localization by …

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Targeting Article: Control Circadian Rhythm?

Advanced Targeting Systems announces the release of Melanopsin-SAP (Cat. #IT-44), a reagent that specifically eliminates intrinsically photosensitive retinal ganglion cells (ipRGCs) that contain melanopsin. This material is described in Göz et al.[1] and consists of an antibody to an extracellular domain conjugated to saporin. The ipRGCs, with their amazing long processes, have become major players …

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Cover Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in extinction of conditioned fear.

Contributed by Ekaterina Likhtik Columbia University,New York Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032 Introduction by Douglas Lappi, Ph.D., President/CSO: This quarter’s Cover Article is from Ekaterina Likhtik who reprises her recently published work in Nature 454:642-645. In the News and Views, Sah and Westbrook comment that “Neuronal receptors in these circuits—such as …

Cover Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in extinction of conditioned fear. Read More »