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Targeting Tools: Anti-Saporin

Saporin is a plant enzyme with N-glycosidase activity that depurinates a specific nucleotide in the ribosomal RNA 28S, thus irreversibly blocking protein synthesis. Affinity-purified Anti-Saporin rabbit polyclonal (Cat. #AB-41AP) is the most recent addition to our line of Saporin antibodies. These antibodies can be used as controls with our Saporin-conjugate immunotoxins, for immunoblotting, and in

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Targeting Article: Control Circadian Rhythm?

Advanced Targeting Systems announces the release of Melanopsin-SAP (Cat. #IT-44), a reagent that specifically eliminates intrinsically photosensitive retinal ganglion cells (ipRGCs) that contain melanopsin. This material is described in Göz et al.[1] and consists of an antibody to an extracellular domain conjugated to saporin. The ipRGCs, with their amazing long processes, have become major players

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Cover Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in extinction of conditioned fear.

Contributed by Ekaterina Likhtik Columbia University,New York Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032 Introduction by Douglas Lappi, Ph.D., President/CSO: This quarter’s Cover Article is from Ekaterina Likhtik who reprises her recently published work in Nature 454:642-645. In the News and Views, Sah and Westbrook comment that “Neuronal receptors in these circuits—such as

Cover Article: Selective lesions of amygdala intercalated neurons using the Dermorphin-SAP immunotoxin reveal their role in extinction of conditioned fear. Read More »

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