08q1

Targeting Trends Newsletter 08q1

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Annual SfN Poster Award (page 2) Upcoming Events (page 2) Teaser Winners (page 4) FGF-SAP, Anti-nAChR, and SP-CTA (page 7) Page 1 Page 5 Page …

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Targeting Tools: Anti-AChR

Species Reactivity: Human, Rat, Mouse, Rabbit Anti-AChR (Cat. #AB-N36) binds with high affinity to the AChR subtype with 59 kDa ACh-binding subunits, but with considerably lower affinity to the AChR subtype with 75 kDa subunits. Anti-AChR binds to the main immunogenic region on α1 subunits of muscle-type AChRs. Reference 1. Schoepfer R, Halvorsen SW, Conroy …

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Targeting Topics 08q1

Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML Mol Cancer Ther 6(11):2995-3008, 2007. The human transferrin receptor (hTfR) is overexpressed in malignant cells. Using Advanced Targeting …

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Cover Article: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP

Contributed by Kevin C.H. Pang, Xilu Jiao and Richard J. ServatiusNeuroscience Dept, New Jersey Med Sch – UMDNJ and VA Med Ctr – East Orange, NJ The medial septum and diagonal band of Broca (MSDB) provide a major afferent pathway to the hippocampus.[1] Cholinergic and GABAergic neurons are the main components of this pathway, but …

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