2008, issue 1: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP / by Pang KCH, Jiao X, Servatius RJ / featuring GAT1-SAP (Cat. #IT-32) SFN Poster of the Year Targeting Talk: Secondary Conjugates & Reducing Agents Targeting Tools: New Products Stimulate Instead of Eliminate (SP-CTA [Substance …
SP-CTA (Cat. #IT-39) is an exciting new tool for use in the research of neurokinin (NK-1) receptor-expressing cells of the central nervous system. A conjugate of the substance P molecule and the catalytic subunit of Cholera toxin, this product can be used very effectively in vivo for increasing sensitization of these neuronal cells. Selectively targeting …
Species Reactivity: Human, Rat, Mouse, Rabbit Anti-AChR (Cat. #AB-N36) binds with high affinity to the AChR subtype with 59 kDa ACh-binding subunits, but with considerably lower affinity to the AChR subtype with 75 kDa subunits. Anti-AChR binds to the main immunogenic region on α1 subunits of muscle-type AChRs. Reference 1. Schoepfer R, Halvorsen SW, Conroy …
FGF-2, or basic fibroblast growth factor, binds all of the FGF receptors with high affinity. We have used this molecule to produce FGF-SAP (Cat. #IT-38), which has a healthy experimental publication record (“FGF” and “saporin” in PubMed: 25 hits). It has been used to clean primary cultures of fibroblasts.[1] It was important in determining the …
Secondary Conjugates I’m using your secondary conjugate Mab-ZAP (Cat. #IT-04) and it’s not killing my cells. Are you following the protocol on the data sheet? It’s described in detail in the article by Kohls et al. (1) No, I’m doing flow cytometry. I have 70,000 cells per well. I mix Mab-ZAP with my primary antibody …
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Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells Daniels TR, Ng PP, Delgado T, Lynch MR, Schiller G, Helguera G, Penichet ML Mol Cancer Ther 6(11):2995-3008, 2007. The human transferrin receptor (hTfR) is overexpressed in malignant cells. Using Advanced Targeting …
Contributed by Kevin C.H. Pang, Xilu Jiao and Richard J. ServatiusNeuroscience Dept, New Jersey Med Sch – UMDNJ and VA Med Ctr – East Orange, NJ The medial septum and diagonal band of Broca (MSDB) provide a major afferent pathway to the hippocampus.[1] Cholinergic and GABAergic neurons are the main components of this pathway, but …