06q2

Targeting Trends 2006 Newsletter

2006, issue 1: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin / by Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F / featuring CCK-SAP (Cat. #IT-31) SFN Poster of the Year Targeting Talk: LPS Content Targeting Tools: Streptavidin-ZAP (Cat. #IT-27) and Biotinylation Service …

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Targeting Tools: Fluorescent Conjugates

Antibodies conjugated to fluorescent dyes are vibrant and vital tools at a scientist’s disposal. ATS currently has six fluorescent conjugates in our catalog: Cy3-labeled 192-IgG (Cat. #FL-01), FITC-labeled Anti-Saporin (Cat. #FL-02), Alexa 488-labeled 192-IgG (Cat. #FL-03), FITC-labeled Goat anti-rabbit IgG (Cat. #FL-04), Cy3- labeled anti-NGFr (Cat. #FL-05), and Cy5-labeled anti- NGFr (Cat. #FL-06). ATS also …

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Targeting Topics 06q2

Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs. Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. Toxicol Sci 91(1):286-298, 2006. SP-SAP (Cat. #IT-07) has been shown to reverse neuropathic pain behavior in rodents and prevent the formation of …

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Cover Article: Targeted Toxins in Pain

Summary of contribution to “Recontres en toxinologie, 2005”by Ronald G. Wiley, Neurology Service (127) – VA TVHS, 1310 24th Avenue, South, Nashville, TN 37212 The use of targeted toxins in neuroscience research has evolved over the past twenty-plus years from original suicide transport lesions using ricin to highly selective neuron type-specific lesions made with immunotoxins, …

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