Read the 2006 Newsletters 2006, issue 1: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin / by Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F / featuring CCK-SAP (Cat. #IT-31) SFN Poster of the Year Targeting Talk: LPS Content Targeting Tools: Streptavidin-ZAP (Cat. …
Streptavidin-ZAP (Cat. #IT-27) Saporin conjugated to streptavidin is one of the most useful reagents that we have produced at ATS. It has been used in a wide variety of studies both in academic research and pharmaceutical/biotech labs. Workers are able to easily see if their molecule, that is biotinylated, is internalized by the target cells. …
Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning. Fontan-Lozano A, Troncoso J, Munera A, Carrion AM, Delgado-Garcia JM. Learn Mem 12(6):557-563, 2005. Classical conditioning of eyeblink responses can be used to evaluate cognitive deficits. The authors lesioned the medial septum/diagonal band of rats with 200 ng of 192-IgG-SAP (Cat. #IT-01), then examined classical …
Contributed by Josephine Lai, Wenjun Zhang, Hamid Badghisi, Victor J. Hruby(1) and Frank Porreca, Departments of Pharmacology and Chemistry(1), The University of Arizona, Tucson, AZ 85724. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers the biological activity …