06q1

Targeting Trends 2006 Newsletter

2006, issue 1: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin / by Lai J, Zhang W, Badghisi H, Hruby VJ, Porreca F / featuring CCK-SAP (Cat. #IT-31) SFN Poster of the Year Targeting Talk: LPS Content Targeting Tools: Streptavidin-ZAP (Cat. #IT-27) and Biotinylation Service …

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Targeting Tools: Streptavidin-ZAP

Streptavidin-ZAP (Cat. #IT-27) Saporin conjugated to streptavidin is one of the most useful reagents that we have produced at ATS. It has been used in a wide variety of studies both in academic research and pharmaceutical/biotech labs. Workers are able to easily see if their molecule, that is biotinylated, is internalized by the target cells. …

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Targeting Talk: LPS Content

In a recent experiment using a saporin-antibody conjugate injected systemically we saw changes in dendritic cells that could be consistent with an LPS effect. Does ATS test for LPS and has this ever been identified as a problem before? Yes, this can happen, but we here at ATS will swear innocence. One of our collaborators …

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Targeting Topics 06q1

Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning. Fontan-Lozano A, Troncoso J, Munera A, Carrion AM, Delgado-Garcia JM. Learn Mem 12(6):557-563, 2005. Classical conditioning of eyeblink responses can be used to evaluate cognitive deficits. The authors lesioned the medial septum/diagonal band of rats with 200 ng of 192-IgG-SAP (Cat. #IT-01), then examined classical …

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Cover Article: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin

Contributed by Josephine Lai, Wenjun Zhang, Hamid Badghisi, Victor J. Hruby(1) and Frank Porreca, Departments of Pharmacology and Chemistry(1), The University of Arizona, Tucson, AZ 85724. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers the biological activity …

Cover Article: The Biologically Active Cholecystokinin (26-33) peptide, [Tyr2-SO3]CCK-8, Retains High Affinity for CCK2 Receptors after Covalent Conjugation to Saporin Read More »