04q3

Targeting Trends 2004 Newsletter

2004, issue 1: Cholinergic Deafferentation of the Entorhinal Cortex Impairs Working Memory for Novel, but not Familiar Stimuli in a Delayed Non-Match to Sample (DNMS) Task / by McGaughy J / featuring 192-IgG-SAP (Cat. #IT-01) ATS Gets New Facility for SP-SAP Production SFN Poster of the Year Targeting Talk: Not the Right Stuff Targeting Tools: …

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Targeting Tools: acLDL-SAP

It’s routine for primary neuronal cultures to have “contamination” with naturally occurring microglia. But what happens when you don’t want these little creatures or the cytokines and cytotoxins that they release? Or you want to eliminate any effect that microglia have on neurons or astrocytes? ATS has the cheap, effective and very simple solution for …

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Targeting Topics 04q3

Cognitive effects of neurotoxic lesions of the nucleus basalis magnocellularis in rats: differential roles for corticopetal versus amygdalopetal projections. Beninger RJ, Dringenberg HC, Boegman RJ, Jhamandas K. Neurotox Res 3(1):7-21, 2001. The cholinergic hypothesis states that projections of cholinergic neurons from the nucleus basalis magnocellularis to cortical and amygdalar targets are important in memory. This …

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Drug Development Update

Chronic pain conditions are often caused by ongoing disease states or tissue damage that create sensitization of both the primary afferents (nerves that convey impulses from the outer part of the body) and spinal cord neurons. This sensitization results in a persistent increased sensitivity to both noxious (hyperalgesia) and non-noxious (allodynia) stimuli. Many persistent pain …

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Cover Article: The Discovery of Saporin

Contributed by Dr. Fiorenzo Stirpe, Dipartimento di Patologia sperimentale, Università di Bologna, I-40125 Bologna, Italy Saporin from Saponaria officinalis (soapwort plant of the Caryophyllaceae family) was discovered as part of research on plant toxins we undertook around 1970, when we became interested in the study of the mechanism of action of ricin. Ricin, from Ricinus …

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