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Targeting Tools: Rat-ZAP

Advanced Targeting Systems is pleased to announce the arrival of its newest second immunotoxin, Rat-ZAP (Cat. #IT-26). This new screening agent is constructed from goat anti-rat IgG conjugated to saporin. Like the other second immunotoxins, Hum-ZAP, Mab-ZAP and Rab-ZAP, it converts your primary antibody, in this case a rat IgG, into a potent cytotoxic agent …

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Targeting Article: CCK-SAP in Binding Studies

Our thanks to Drs. Frank Porecca, Victory Hruby and Josephine Lai, Department of Pharmacology, The University of Arizona Health Sciences Center for sharing the results of their studies. Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers …

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ATS Receives $2.4 M Award for SP-SAP Drug Development

ATS has received a Small Business Innovation Research (SBIR) grant from the National Institute of Mental Health (NIMH) under the program announcement for competing continuation awards for pharmacologic agents and drugs for mental disorders. This three-year, $2.4 million award is a continuation of Phase II funding for the development of a drug for the treatment …

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Cover Article: Subplate Neurons and Functional Maturation of Thalamocortical Synapses

Contributed by Dr. Patrick O. Kanold, Dept Neurobiology, Harvard Medical School, Boston, MA 02115.Dr. Kanold summarizes his work with ME20.4-SAP. A complete report was published in Science 301:521-525. The processing of information in the visual system happens in multiple stages. Retinal neurons in the eye connect to neurons in the lateral geniculate nucleus (LGN), that …

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