Tag Archives: 02q2

Targeting Trends Newsletter 02q2

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights It’s Twins!(page 2) Toxin Safety (page 5) OX7-SAP (page 7)

Targeting Tools: OX7 and OX7-SAP

OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original […]

Targeting Talk: Toxin Safety

Q: Your recent issue of Targeting Trends stated that it was unlikely that saporin compounds or constituents would be excreted in urine or feces. However, you acknowledge that experimental data is lacking. Have there been any tests of animal urine or feces for saporin content? My animal care staff are concerned. A: One of the […]

Targeting Topics 02q2

GABAergic septohippocampal neurons are not necessary for spatial memory. Pang KC, Nocera R, Secor AJ, Yoder RM. Hippocampus 11(6):814-827, 2001. PMID: 11811676 The medial septum and diagonal band of Broca (MSDB) are necessary for spatial memory. Both cholinergic and GABAergic neuronal populations are present in the MSDB. 192-Saporin (Cat. #IT-01) was used to eliminate cholinergic […]

SP-SAP licensed to Cell Targeting Technologies

Advanced Targeting Systems has exclusively licensed the Substance P- Saporin (SP-SAP) compound to Cell Targeting Technologies for development as a pharmaceutical agent. ATS and collaborators at University of Minnesota and University of California, San Diego have completed several preclinical studies using SP-SAP and have thus far found it safe and effective in two animal models. […]

Cover Article: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not

Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award. […]