02q2

Targeting Trends 2002 Newsletter

Read the 2002 Newsletters and receint scientific references 2002, issue 1: Control Conjugates: The Perfect Companion for Targeted Toxins / by Lappi DA / featuring Control Conjugates SFN Poster of the Year Targeting Talk: Toxin Safety Targeting Tools: Serotonin Transporter Antibody 2002, issue 2: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not  / by Blanco-Centurion …

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Targeting Tools: OX7 and OX7-SAP

OX7-SAP is a cytotoxin to many types of neurons. It is one of the most potent of the saporin immunotoxins— the conjugates between a cell surface antibody and the ribosome-inactivating protein from Saponaria officinalis. The reason for the potency could be due to the construct’s grand tradition. The antibody, OX7, is one of the original …

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Cover Article: HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not

Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award. …

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